Methotrexate 59-05-2
KOSHER ISO FDA 3 Inquiries
59-05-2
Pharmaceutical Grade
99%
shenzhen
Flying
1kg
2025-10-05
vitamin
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceOdorless yellow to orange-brown crystalline powder.
Methotrexate is an alkaloid anticancer drug available in tablet or injectable liquid form. A chemotherapy drug that interferes with DNA and RNA synthesis. It is also an insect chemosterilant.
UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.
Most common impurities are 10-methylpteroylglutamic acid, aminopterin and pteroylglutamic acid. Purify it by chromatography on Dowex-1 acetate, followed by filtration through a mixture of cellulose and charcoal. It has been recrystallised from aqueous HCl or by dissolution in the minimum volume of N NaOH and acidified until precipitation is complete, filter or better collect by centrifugation, wash with H2O (also by centrifugation) and dry at 100o/3mm. It has UV: max at 244 and 307nm ( 17300 and 19700) in H2O at pH 1; 257, 302 and 370nm ( 23000, 22000 and 7100) in 2O at pH 13. [Momle Biochemical Preparations 8 20 1961, Seeger et al. J Am Chem Soc 71 1753 1949.] It is a potent inhibitor of dihydrofolate reductase and is used in cancer chemotherapy. [Blakley The Biochemistry of Folic Acid and Related Pteridines, North-Holland Publ Co., Amsterdam, NY, pp157-163 1969, Beilstein 26 IV 3833.] It is CARCINOGENIC; HANDLE WITH EXTREME CARE.
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.CertificatesBasic Info-
Product Name:
Methotrexate
Other Name:METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe
CAS No.:59-05-2
Molecular Formula:C20H22N8O5
InChIKeys:FBOZXECLQNJBKD-ZDUSSCGKSA-N
Molecular Weight:454.44
Exact Mass:454.44
BRN:70669
EC Number:200-413-8
UNII:YL5FZ2Y5U1
NSC Number:740
UN Number:3249
TSCA:TSCA listed
DSSTox ID:DTXSID4020822
NCI Thesaurus Code:C642
Color/Form:Light yellow to yellow
ATC Code:L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents
HScode:29335995
Categories:
Characteristics-
PSA:
211
XLogP3:-1.8
Appearance:powder
Density:1.4080 (rough estimate)
Melting Point:195°C
Boiling Point:561.26°C (rough estimate)
Flash Point:11℃
Refractive Index:1.6910 (estimate)
Water Solubility:Insoluble. <0.1 g/100 mL at 19 ºC
Storage Conditions:−20°C
Vapor Pressure:2.1X10-19 mm Hg at 25 deg C /Estimated/
Toxicity:LD50 oral in rat: 135mg/kg
Specific rotation:Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)
PKA:pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
Henrys Law Constant:Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/
Dissociation Constants:4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/
Collision Cross Section:196.2 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/
Air and Water Reactions:Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.
Reactive Group:Acids, Carboxylic
Reactivity Profile:Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.
Critical Temperature & Pressure:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted
India
METHOTREXATE IP/BP/USP
1.00 KG Jul 4, 2025
India
Methotrexate USP
5 KG Aug 18, 2026
India
Methotrexate
1.00 KG Dec 11, 2023 Post an enquiry for this product
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