9-Aminocamptothecin RC10713
91421-43-1
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Details
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Seller Information
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DescriptionECHEMI Editorial Reference9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity.
9-Aminocamptothecin is a pyranoindolizinoquinoline.|Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.|Aminocamptothecin is a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)Basic Info-
Product Name:
9-Aminocamptothecin
Other Name:1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-amino-4-ethyl-4-hydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-amino-4-ethyl-4-hydroxy-,(S)-;(4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Aminocamptothecin;NSC 603071;9-Amino-20(S)-camptothecin;(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS No.:91421-43-1
Molecular Formula:C20H17N3O4
InChIKeys:InChIKey=FUXVKZWTXQUGMW-FQEVSTJZSA-N
Molecular Weight:363.37
Exact Mass:363.37
UNII:5MB77ICE2Q
NSC Number:603071
NCI Thesaurus Code:C1488
HScode:2934999090
Categories:
Characteristics-
PSA:
107.44000
XLogP3:0.44
Appearance:Orange-yellow powder
Density:1.6±0.1 g/cm3
Melting Point:142.0-145.0 °C
Boiling Point:819.6±65.0 °C at 760 mmHg
Flash Point:449.5±34.3 °C
Refractive Index:1.771
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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