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9-Aminocamptothecin

9-Aminocamptothecin structure

CAS No:
91421-43-1
Formula:
C20H17N3O4
Chemical Name:
9-Aminocamptothecin
Synonyms:
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-amino-4-ethyl-4-hydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-amino-4-ethyl-4-hydroxy-,(S)-;(4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Aminocamptothecin;NSC 603071;9-Amino-20(S)-camptothecin;(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Categories:
Natural Products > Alkaloids

Description

9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity.

9-Aminocamptothecin is a pyranoindolizinoquinoline.|Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.|Aminocamptothecin is a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)

9-Aminocamptothecin Basic Attributes

Molecular Weight：

363.37

Exact Mass：

363.37

UNII：

5MB77ICE2Q

NSC Number：

603071

NCI Thesaurus Code：

C1488

HScode：

2934999090

Characteristics

PSA：

107.44000

XLogP3：

0.44

Appearance：

Orange-yellow powder

Density：

1.6±0.1 g/cm3

Melting Point：

142.0-145.0 °C

Boiling Point：

819.6±65.0 °C at 760 mmHg

Flash Point：

449.5±34.3 °C

Refractive Index：

1.771

Safety Information

RTECS Number：

UQ0490500

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

9-amino-20(S)-camptothecin

9-Aminocamptothecin Use and Manufacturing

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent. Chinese medicine reference substance

Computed Properties

Molecular Weight:363.4
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:363.12190603
Monoisotopic Mass:363.12190603
Topological Polar Surface Area:106
Heavy Atom Count:27
Complexity:775
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 9-Aminocamptothecin

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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9-Aminocamptothecin

CAS No.: 91421-43-1

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

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9-Aminocamptothecin

CAS No.: 91421-43-1

Grade: Industrial Grade

Content: 95%

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Guide of 9-Aminocamptothecin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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9-Aminocamptothecin

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