Dopamine Hydrochloride,CAS 62-31-7

Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.Target: Dopamine ReceptorDopamine (or 3,4-dihydroxyphenethylamine) is a neuroendocrine transmitter in the catecholamine and phenethylamine families that plays a number of important roles in the brain and bodies of humans. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system. Outside the nervous system, dopamine fun
Dopamine hydrochloride is a catecholamine.|Dopamine Hydrochloride is the hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1- and beta-1- adrenergic receptors. Mediated through myocardial beta-1-adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1-adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.|One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Dopamine hydrochloride Use and Manufacturing
Methods of Manufacturing
Derived from the opening of piperidine. Piperonylamine and phenol were added to the reaction pot, cooled, hydrochloric acid was slowly added, and the temperature was raised to 110°C and refluxed for 12-44h. After the reaction reaches the end, it is a little cold, and it is stirred evenly by adding water. Set aside for separation and remove the phenol layer. The water layer was extracted with isopropyl acetate, and the water layer after extraction was evaporated to dryness under reduced pressure (8.0 kPa), then 1/2 amount of ethanol and hydrochloric acid were added, and dissolved by heating. Cool, crystallize, filter, wash the filter cake with ethanol, and dry to get the finished product. The yield was 74%.
Uses
dopaminergic