Anti-depression ,anti-tumor effect with St.John's Wort extract hypericin 0.3% by UV

St.John's wort extract Effects:

1. Antidepressant action: Hypericin and flavonoid components demonstrate significant antidepressant effects by inhibiting monoamine oxidase activity in the nervous system. This reduces the synaptic reuptake of monoamine neurotransmitters such as serotonin and dopamine while simultaneously suppressing glutamate release, thereby effectively alleviating depressive symptoms with fewer side effects than standard antidepressant medications.

2. Antiviral Effects: Hypericin inhibits multiple viruses including HIV, influenza, herpes, and hepatitis B. It exerts anti-HIV activity by reducing reverse transcriptase activity and suppresses influenza virus replication.

3. Antibacterial effects: Hypericum perforatum total extract exhibits bacteriostatic and bactericidal activity against multiple bacteria, including Clostridium tetracoccus, Staphylococcus aureus, and Bacillus subtilis. It demonstrates potent inhibitory and lethal effects against 11 clinically isolated Gram-positive bacterial strains resistant to common antibiotics.

4. Antitumour Effects: Hypericin inhibits the growth of MT-450 breast cancer cells and suppresses the proliferation of leukaemia cell lines K562 and U937, as well as the malignant glioma cell line LN229. It induces tumour cell apoptosis by activating mitochondrial-mediated signal transduction pathways.

5. Other effects: Hypericum perforatum also exhibits anti-inflammatory, analgesic, sedative-hypnotic, immunomodulatory, memory-enhancing, anti-ageing, and myocardial protective properties.