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Home > Pharmaceutical Intermediates > Antispasticity Agents > Diphenhydramine hydrochloride for Sale > Top Grade 99% USP Diphenhydramine Hydrochloride
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Top Grade 99% USP Diphenhydramine Hydrochloride

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Unit Price: Get Latest Price
CAS No.:

147-24-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

10g/bag, 50g/bag, 100g/bags or other quantities

Price valid (until):

2025-10-29

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Name

    Diphenhydramine Hydrochloride

    CAS number

    147-24-0

    Description

    The primary therapeutic applications of diphenhydramine hydrochloride span multiple medical areas due to its diverse pharmacological profile. It is widely used for managing allergic conditions including seasonal allergies, urticaria, and allergic rhinitis through its histamine blockade action.

    Structural formula

     Shop Top Grade 99% USP Diphenhydramine Hydrochloride-Detailed Image 1

    Molecular Formula

    C17H22ClNO

    Molecular Weight

    291.82 g/mol

    Appearance

    White powder

    Quality Standard

    99%

    Storage Condition

    Cool dry place( away from the light)

    Shelf Life

    >2 years if stored properly

    Sample package

    Aluminium foil bag

    Commercial package

    Aluminium Tin, Fiber drum

    Origin

    China

    The primary therapeutic applications of diphenhydramine hydrochloride span multiple medical areas due to its diverse pharmacological profile. It is widely used for managing allergic conditions including seasonal allergies, urticaria, and allergic rhinitis through its histamine blockade action. The medication is equally employed as a sleep aid due to its pronounced sedative effects, available in over-the-counter formulations specifically for insomnia management. Additional applications include antiemetic use for motion sickness, treatment of drug-induced extrapyramidal symptoms, and as a topical agent for relieving itching and skin irritation. The compound is formulated in various delivery systems including oral tablets, capsules, liquids, injectable solutions, and topical creams to accommodate different clinical needs.

     

    Application Market

    The market for diphenhydramine hydrochloride is extensive and well-established within the over-the-counter pharmaceutical sector, with significant global presence across multiple product categories. As a generic medication, it is manufactured by numerous pharmaceutical companies worldwide and is included in many national essential medicine lists. The market distribution encompasses retail pharmacies, supermarkets, convenience stores, and online platforms, making it highly accessible to consumers. Product variations include single-ingredient formulations and combination products for cold and allergy relief, with particular strength in the sleep aid segment. Despite the development of newer non-sedating antihistamines, diphenhydramine maintains substantial market share due to its proven efficacy, low cost, and consumer familiarity.

     

    Important Considerations

    Appropriate use of diphenhydramine hydrochloride requires careful attention to its sedative properties and potential interactions. Users should avoid activities requiring mental alertness, such as driving or operating machinery, after administration due to significant drowsiness. The medication potentiates the effects of other central nervous system depressants including alcohol, benzodiazepines, and opioids. Important contraindications include narrow-angle glaucoma, severe respiratory conditions, and prostate enlargement. Recommended dosing intervals should be strictly followed, with special caution advised for elderly patients who are more susceptible to confusion and dizziness. The product should be stored at controlled room temperature away from moisture and light. Patients with chronic medical conditions or those taking multiple medications should consult healthcare providers before use.

     


    Package Image

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    FAQ

    Q1. Can I get a free sample?

    We can send you a samll free sample, and you only need to pay for the shipping cost.


    Q2. What is the HyperChem payment term?

    T/T in advance
    LC at sight
    DP at sight

    Bank transfer

    PayPal

    Bitcoin...


    Q3. What is HyperChem shipment policy?

    Our policy is to strive for the quickest shipment time possible.

    For ready stock samples, they are usually shipped within 3 working days after payment received.
    For non-ready stock, please contact HyperChem sales team to negotiate.


    Q4. What is HyperChem shipment term?

    By Express  
    FedEx  UPS  DHL  EMS                               
    Fast: 3-7 days around, high cost, door to door service

    By Air                                        
    Suitable for more than 50kg 
    Fast: 3-7 days, hight cost, port to port, professional broker needed 

    By Sea
    Suitable for more than 500kg      
    Fast: 7-45 days, low cost, port to port, professional broker needed 


    We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.


    Q5. What HyperChem will provide after shipment?

    For sample orders: 
    After shipment is done, an timely email including:

    1. Track details (Fedex /TNT/DHL/EMS Track number)
    2. Packaging photo
    3. COA, MSDS, etc
    4. Dispatch date & Estimated arriving time
    5. Shipping invoice

    For commercial orders
    A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.



    Company Profile

    Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.


    Among them, our key client industrial sectors around the global are:

    Pharmaceuticals
    Nutrition Ingredients/ Dietary supplements
    Cosmetic Ingredients
    Food Ingredients
    Veterinary API
    Agriculture fertilizer
    Custom Synthesis lab supply


    HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.




    ECHEMI Editorial Reference
    White or almost white, crystalline powder.ChEBI: The hydrochloride salt of diphenhydramine.Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
    Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992)
    Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992)|Diphenhydramine Hydrochloride is the hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine hydrochloride competitively blocks H1receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.|A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

    Certificates

    Basic Info
    Product Name:

    Diphenhydramine hydrochloride

    Other Name:

    Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-,hydrochloride (1:1);Ethylamine,2-(diphenylmethoxy)-N,N-dimethyl-,hydrochloride;Ethanamine,2-(diphenylmethoxy)-N,N-dimethyl-,hydrochloride;Bena;Benadryl;Benzhydramine hydrochloride;2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride;β-Dimethylaminoethyl benzhydryl ether hydrochloride;Diphenhydramine hydrochloride;2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride;Difenhydramine hydrochloride;Denydryl;Dimedrol;Dimedrol hydrochloride;Allergan;Allergival;Benadril hydrochloride;Restamin;Vena;Resmin;Benzhydrol β-dimethylaminoethyl ether hydrochloride;Halbmond;Benocten;Sekundal D;Allergina;Noctomin;Bagodryl;Bena-Fedrin;Amidryl;Alledryl;Fenylhist;Bax;Dibondrin;S 8;Wehydryl;Benylin;Syntedril;Sedopretten;Diphantine;Benodine;Histacyl;Benzantin;Asdrin;Benison;Theraflu;Dimedrolum;Psilo-Balsam;[2-(Diphenylmethoxy)ethyl]dimethylamine hydrochloride;8052-21-9

    CAS No.:

    147-24-0

    Molecular Formula:

    C17H21NO.ClH

    InChIKeys:

    InChIKey=PCHPORCSPXIHLZ-UHFFFAOYSA-N

    Molecular Weight:

    291.81600

    Exact Mass:

    291.13900

    EC Number:

    205-687-2

    UNII:

    TC2D6JAD40

    NSC Number:

    756729|33299

    DSSTox ID:

    DTXSID4020537

    NCI Thesaurus Code:

    C300

    HScode:

    2933990090

    Categories:

    Antispasticity Agents

    Characteristics
    PSA:

    12.47000

    XLogP3:

    4.15620

    Appearance:

    Diphenhydramine hydrochloride appears as white or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6. (NTP, 1992)

    Density:

    1.024g/cm3

    Melting Point:

    166-170 °C

    Boiling Point:

    163-167 °C @ Press: 3 Torr

    Flash Point:

    101.5ºC

    Refractive Index:

    1.5800 (estimate)

    Water Solubility:

    H2O: 1000 g/L

    Storage Conditions:

    Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition so

    Toxicity:

    LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)

    Collision Cross Section:

    162.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Air and Water Reactions:

    Water soluble. Aqueous solutions are acidic.

    Reactive Group:

    Ethers

    Reactivity Profile:

    DIPHENHYDRAMINE HYDROCHLORIDE gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

    Location:

    Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2013

    Certifications:

    Certification Report by Bureau Veritas

    About HyperChem

    Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

    Our Competitiveness

    One-stop supply

    Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

    Among all the pharmaceuticals,

    90% of them with GMP certificates,

    85% of them with DMF files and

    50% of them passed FDA approval,

    30% get CEP certificate

    20% are new R&D products.

    Custom Repackaging Service


    We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

    Quality Control/Quality Assurance


    HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

    All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

    Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

    Professional

    Transparent Communication

    Fast Reaction,

    Professional Suggestion

    Beyond Expectation.

    We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

  • Inquiry History
    8 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Diphenhydramine Hydrochloride

    200 G Feb 12, 2026
    United Kingdom

    API Raw Material Diphenhydramine Hydrochloride CAS:147-24-0

    Jan 10, 2026
    United States

    DIPHENHYDRAMINE HYDROCHLORIDE

    100 G Sep 25, 2025
    Australia

    Diphenhydramine hydrochloride

    1 KG Dec 2, 2024
    United States

    Diphenhydramine hydrochloride

    100 G May 8, 2026
    Thailand

    Diphenhydramine Hydrochloride

    1 KG Nov 19, 2024
    United States

    Diphenhydramine Hydrochloride 99% -5-00472

    25 KG Sep 6, 2023
    Nigeria

    Chloropheniramine

    200 G Jun 26, 2025
    Post an enquiry for this product
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