High Quality 90% Chondroitin sulfate CAS 9007-28-7 Chondroitin sulfate sodium from bovine, shark, chicken, porcine source

Chondroitin sulfate More Info

Chondroitin sulfate is a dietary supplement commonly used to treat osteoarthritis and other joint disorders. It is a sulfated glycosaminoglycan (GAG) found naturally in cartilage, which provides structure and support to joints.

Mechanism of Action

Chondroitin sulfate is widely found in human and animal cartilage tissue. Its medicinal preparation mainly contains chondroitin sulfate A and chondroitin sulfate C two isomers, different species, age and other animals in the cartilage of chondroitin sulfate content is different.

Its pharmacological effects are manifested as follows:

1, chondroitin sulfate can remove lipids and lipoproteins in the blood of the body, remove cholesterol from the blood vessels around the heart, prevent and control atherosclerosis, and increase the conversion rate of lipids and fatty acids in the cells.

2, chondroitin sulfate can effectively prevent and control coronary heart disease. For experimental atherosclerosis model has anti-atherosclerosis and anti-atherogenic plaque formation; increase atherosclerosis coronary artery staging or collateral circulation, and can accelerate experimental coronary atherosclerosis or embolism caused by myocardial necrosis or degeneration of healing, regeneration and repair.

3, It can increase the biosynthesis of cellular messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) as well as having the effect of promoting cellular metabolism.

4, low anticoagulant activity. Chondroitin sulfate has a mild anticoagulant effect, each lmg of chondroitin sulfate A is equivalent to 0.45 U heparin anticoagulant activity. This anticoagulant activity does not depend on antithrombin III and play a role, it can play an anticoagulant activity through the fibrinogen system.

5, chondroitin sulfate also has anti-inflammatory, accelerate wound healing and anti-tumor effects.

Applications

1. Chondroitin sulfate has been used for a long time as a health food or health care drug to prevent and treat coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia and other diseases, with no obvious toxic side effects, and it can significantly reduce the morbidity and mortality of patients with coronary heart disease. Long-term clinical application found in the arteries and veins wall deposits of fat and other lipids can be effectively removed or reduced, can significantly reduce plasma cholesterol, thus preventing the formation of atherosclerosis.
2. Chondroitin sulfate is used in the treatment of neuralgia, neuropathic migraine, arthralgia, arthritis, and scapular joint pain, pain after abdominal surgery.
3. It is effective in preventing and treating the hearing disorder caused by streptozotocin as well as the hearing difficulty and tinnitus caused by various noises.
4. It has auxiliary therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcer.
5. In recent years, it has been reported that chondroitin in shark cartilage has anti-tumor effects. In addition, chondroitin sulfate is also used in cosmetics and traumatic wound healing agent.
6. Chondroitin sulfate is also used in eye drops.

Safety and Side Effects

Chondroitin sulfate is generally well-tolerated, but some side effects may occur:
Common Side Effects:
Gastrointestinal disturbances (nausea, diarrhea)
Fatigue
Headache
Less Common Side Effects:
Allergic reactions (rare)
Increased risk of bleeding (in patients taking anticoagulants)
Serious side effects are rare but require medical attention if they occur.

Routes of Administration

Chondroitin sulfate is administered orally in capsule, tablet, or powder form.

Pharmacokinetics

Absorption: Chondroitin sulfate is poorly absorbed from the gastrointestinal tract, which limits systemic exposure.
Distribution: It remains primarily localized to the gastrointestinal tract.
Metabolism: Minimal systemic metabolism occurs due to low absorption.
Elimination: Chondroitin sulfate is primarily excreted in the urine and feces.

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