4-(phenylsulfamoyl)benzoic acid cas 6314-72-3 support custom synthesis

· CAS Number: 6314-72-3
· Chemical Name: 4-(Phenylamino sulfonyl)benzoic acid
· Common Name: N-Phenylsulfamoylbenzoic acid
· Molecular Formula: C₁₃H₁₁NO₄S
· Molecular Weight: 277.30 g/mol
Chemical structure and properties
· Structural features: The molecular structure of this compound consists of three key parts:
1. A phenylacetic group, which provides a carboxylic acid (-COOH) functional group, giving it acidity.
2. A sulfonamide group (-SO₂NH-), which is the bridge connecting the two benzene rings and is also an important pharmacophore.
3. A terminal phenyl group.
· Appearance: Usually white or off-white crystalline powder.
· Melting point: Approximately 188 - 190 °C.
· Solubility:
· Due to the presence of its carboxyl group, it can dissolve in alkaline aqueous solutions (such as sodium hydroxide, sodium bicarbonate solutions), forming corresponding salts.
· It may precipitate in strong acids.
· It has certain solubility in common organic solvents (such as ethanol, dimethyl sulfoxide), but has very low solubility in water.
Main Uses and Applications
4-(Phenylsulfonyl)benzoic acid is an important organic synthetic intermediate and a pharmaceutical chemical building block.
1. Pharmaceutical synthetic intermediates:
· This is its primary application. The sulfonamide group is the core structure of many sulfonamide drugs and carbonic anhydrase inhibitors.
· This compound simultaneously possesses two important pharmacophores, the sulfonamide and benzoic acid, making it an ideal starting point for designing and synthesizing novel bioactive molecules.
· It may be used to synthesize compounds with diuretic, lowering intraocular pressure (for treating glaucoma), anti-epileptic or antibacterial activities. Researchers can develop derivatives with different pharmacological activities and selectivity by modifying the carboxyl group and the hydrogen on the sulfonamide.
2. Chemical research:
· In organic synthesis, it serves as a key fragment for constructing more complex molecules.
· It can be used to study the synthetic methodology and the relationship between the structure and activity of sulfonamide compounds.
Safety and Storage
· Hazard: As a chemical substance, its impact on human health is not yet fully clear, but it should be assumed that it may have irritant effects on the eyes, skin and respiratory tract. Swallowing or inhaling may be harmful.
· Stability: Stable under the recommended storage conditions.
· Storage: Should be stored in a sealed container in a cool, dry, well-ventilated place, away from fire sources and incompatible substances.
Summary

CAS 6314-72-3 (4-(Phenylamino sulfonyl)benzoic acid) is a fine chemical with dual functional groups of sulfonamide and benzoic acid. It may not have direct medicinal activity on its own, but its structure determines that it is an important intermediate for synthesizing various pharmacologically active molecules (especially sulfonamide-related drugs). It has specific application value in drug research and development as well as in organic synthesis laboratories.