2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride RC05836
10212-25-6
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial Referencewhite fine crystalline powderChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of ancitabine and hydrogen chloride.
Ancitabine hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of ancitabine and hydrogen chloride. It has a role as an antimetabolite and an antineoplastic agent. It contains an ancitabine(1+).|Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.|Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.Basic Info-
Product Name:
Ancitabine hydrochloride
Other Name:6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,hydrochloride (1:1),(2R,3R,3aS,9aR)-;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,stereoisomer;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,[2R-(2α,3β,3aβ,9aβ)]-;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,hydrochloride;6H-Furo[2′,3′:4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,monohydrochloride,(2R,3R,3aS,9aR)-;2,2′-O-Cyclocytidine hydrochloride;O2,O2′-Anhydro-1-β-arabinofuranosylcytosine hydrochloride;O2,O2′-Anhydro-1-β-D-arabinofuranosylcytosine monohydrochloride;Cyclo-CMP hydrochloride;Cyclocytidine hydrochloride;2,2′-Anhydroarabinosylcytosine hydrochloride;2,2′-Anhydrocytidine hydrochloride;2,2′-Cyclocytidine hydrochloride;2,2′-Anhydro-1-β-D-arabinofuranosylcytosine monohydrochloride;NSC 145668;2,2′-Anhydroaracytidine hydrochloride;2,2′-Anhydro-1-β-D-arabinofuranosylcytosine hydrochloride;Ancitabine hydrochloride;OCTD hydrochloride;130825-73-9;135896-99-0;40390-35-0;42782-87-6;42965-86-6;42968-70-7
CAS No.:10212-25-6
Molecular Formula:C9H11N3O4.ClH
InChIKeys:InChIKey=KZOWNALBTMILAP-JBMRGDGGSA-N
Molecular Weight:261.66
Exact Mass:261.051636
EC Number:233-515-6
UNII:3T6920M469
DSSTox ID:DTXSID6020357
NCI Thesaurus Code:C403
HScode:29213000
Categories:
Characteristics-
PSA:
100.59000
XLogP3:-0.72410
Appearance:White Powder
Density:2.01 g/cm3
Melting Point:248-250 °C
Boiling Point:442ºC at 760 mmHg
Flash Point:221.1ºC
Refractive Index:-21 ° (C=2, H2O)
Water Solubility:H2O 200 ( mg/mL)|EtOAc < 0.1 ( mg/mL)|CHC13 < 0.1 ( mg/mL)
Storage Conditions:−20°C
Specific rotation:-21.8 º (c=2,water)
Collision Cross Section:141.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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