99% API Grade GUANFACINE HCL With Best Price Fast Delivery

Guanfacine hydrochloride More Info

Guanfacine hydrochloride is a synthetic compound classified as a selective α2A-adrenergic receptor agonist. Initially developed and approved for the management of hypertension in adults, its therapeutic application has significantly expanded over time. The hydrochloride salt form enhances the stability and water solubility of the base guanfacine, making it suitable for oral pharmaceutical formulations. Its mechanism of action in the central nervous system involves postsynaptic receptor activation in the prefrontal cortex, which modulates neuronal signaling and improves regulatory control over attention, emotions, and behavior. This distinct central activity, separate from its peripheral cardiovascular effects, underpins its use in neurological and psychiatric conditions.

Uses and Applications

The primary applications of guanfacine hydrochloride span both cardiovascular and neuropsychiatric therapeutics. It is used as an antihypertensive agent, often in combination with other drugs, for managing high blood pressure through its central sympatholytic effect. A major and expanding use is in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents, where it is approved as both a monotherapy and an adjunct to stimulant medications. It is also prescribed for the management of tic disorders, including Tourette syndrome. The medication is formulated into immediate-release and extended-release tablets to accommodate different dosing regimens and therapeutic needs, allowing for tailored treatment approaches.

Application Market

The market for guanfacine hydrochloride is well-established within the neuropsychiatric and cardiovascular pharmaceutical sectors. Following patent expirations, it is available as both branded (e.g., Intuniv® for ADHD) and generic products, making it accessible across diverse healthcare systems. The market is global, with strong presence in North America, Europe, and parts of Asia, driven by the high prevalence of ADHD and the need for non-stimulant treatment options. Distribution channels include retail pharmacies, hospital formularies, and specialized mental health clinics. Its market position is characterized by its role as a second-line or adjunctive therapy for hypertension and a valuable non-stimulant option for ADHD.

Important Considerations

Clinical use of guanfacine hydrochloride requires careful dose initiation and monitoring. Common side effects include sedation, drowsiness, dry mouth, dizziness, and constipation, which often diminish with continued therapy. Abrupt discontinuation should be avoided due to the risk of rebound hypertension; a gradual tapering of the dose is necessary. It is contraindicated in patients with known hypersensitivity and should be used with caution in those with cardiovascular, hepatic, or renal impairment. Drug interactions are possible with other central nervous system depressants and antihypertensive agents. Patients and caregivers should be educated about proper administration, the importance of consistent dosing, and the potential for sedation affecting activities requiring mental alertness.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.