Supply High Purity Pharmaceutical White Powder Atorvastatin Calcium CAS 134523-03-8 USP Standard

Atorvastatin Calcium More Info

Atorvastatin calcium is a medication primarily used for lowering cholesterol levels and treating cardiovascular diseases. It functions by inhibiting the enzyme HMG-CoA reductase, which is crucial in the biosynthesis of cholesterol. This inhibition reduces the liver's production of cholesterol, thereby decreasing plasma levels of low-density lipoprotein (LDL) cholesterol and triglycerides, while also increasing high-density lipoprotein (HDL) cholesterol levels

Mechanism of Action

Atorvastatin acts as a competitive inhibitor of HMG-CoA reductase, the enzyme responsible for catalyzing the conversion of HMG-CoA to mevalonate, a precursor in cholesterol biosynthesis. By inhibiting this enzyme, atorvastatin effectively:
1. Decreases Cholesterol Production: This leads to reduced levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the bloodstream.
2. Increases LDL Receptors: The reduction in hepatic cholesterol concentrations stimulates the upregulation of LDL receptors on liver cells, enhancing the uptake of LDL from the blood and further lowering its levels.
3. Effects on Other Lipoproteins: Atorvastatin also reduces very-low-density lipoprotein (VLDL) and increases high-density lipoprotein (HDL) cholesterol, contributing to improved lipid profiles and reduced cardiovascular risk.

Applications

1. Hyperlipidemia Management: It is effective in treating elevated cholesterol levels, particularly high LDL and triglycerides.
2. Cardiovascular Disease Prevention: Atorvastatin is indicated for reducing the risk of heart attack, stroke, and other cardiovascular events in individuals with risk factors such as diabetes or existing heart disease.
3. Familial Hypercholesterolemia: It is also used in patients with genetic conditions that cause high cholesterol levels.

Routes of Administration

Atorvastatin is administered orally. It is available in various strengths (10 mg, 20 mg, 40 mg, and 80 mg) and can be taken with or without food. Consistency in timing relative to meals can affect absorption rates but does not significantly alter efficacy.

Safety and Side Effects

While atorvastatin is generally well-tolerated, it can cause side effects, some of which can be serious:
Common Side Effects
Muscle pain or weakness
Nausea or upset stomach
Diarrhea
Cold-like symptoms (runny nose, cough)
Joint pain
Serious Side Effects
Myopathy/Rhabdomyolysis: Muscle problems can occur, leading to muscle breakdown and potential kidney damage. Symptoms include unexplained muscle pain, tenderness, or weakness.
Liver Damage: Increased liver enzymes may indicate hepatotoxicity; symptoms include jaundice (yellowing of skin/eyes) and abdominal pain.
Allergic Reactions: Rarely, severe allergic reactions may occur.

Pharmacokinetics

Absorption: Atorvastatin is rapidly absorbed after oral administration, with peak plasma concentrations typically reached within 1 to 2 hours. However, its oral bioavailability is approximately 14% due to extensive first-pass metabolism.
Metabolism: It undergoes significant metabolism primarily via CYP3A4 enzymes in the liver and intestines. The main active metabolite contributes significantly to its therapeutic effects.
Elimination: Atorvastatin and its metabolites are predominantly eliminated via bile without significant renal excretion (less than 1% excreted unchanged).
Half-Life: The elimination half-life ranges from 14 to 19 hours, allowing for once-daily dosing.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

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Suitable for more than 50kg 
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
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2. Packaging photo
3. COA, MSDS, etc
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5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.