7-chloro-[1,2,4]triazolo[1,5-a]pyrimidine cas 52341-91-0 white powder support customized synthesis

The most commonly used name for this substance is Sertraline Hydrochloride.
Here is the detailed introduction about it:
1. Basic Information
· Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalamine hydrochloride
· CAS Number: 52341-91-0
· Molecular Formula: C₁₇H₁₇NCl₂·HCl or C₁₇H₁₈Cl₂NCl (in the form of hydrochloride salt)
· Molecular Weight: 342.70 g/mol
· Appearance: Usually a white to off-white crystalline powder.
2. Chemical Structure and Properties
· Structure: The sertraline molecule consists of a naphthalene ring structure, connected to a dichlorobenzene ring and an amino group. It has a chiral center, and its pharmacological activity mainly comes from the (S,S)-configuration isomer. The commercially available products are usually the racemic mixture of these two enantiomers, but the activity is mainly contributed by the (S,S)-isomer.
· Solubility: Slightly soluble in water, easily soluble in methanol, and slightly soluble in ethanol and acetone.
· Stability: Stable at normal temperature and pressure, but should be protected from light and stored sealed.
3. Main Uses and Importance
The primary use of sertraline hydrochloride is as a psychotropic drug.
It is a selective serotonin reuptake inhibitor.
· Mechanism of action: It achieves its effect by highly selectively and effectively inhibiting the reuptake of the neurotransmitter serotonin (also known as 5-hydroxytryptamine) at the presynaptic membrane of the central nervous system, thereby increasing the concentration of serotonin in the synaptic cleft. Serotonin is closely related to emotions, appetite, sleep, cognition, etc. Elevating its level can produce antidepressant and anti-anxiety effects.
· Indications:
· Severe depression
· Obsessive-compulsive disorder (one of its main indications, effective for both adults and children)
· Panic disorder
· Social anxiety disorder
· Post-traumatic stress disorder
· Premenstrual dysphoric disorder
4. Pharmacology and Market Position
· Development history: Developed by Pfizer, it was first approved for sale in the UK in 1990 and has since been widely used globally (trade name: Zoloft).
· Market position: For many years, sertraline has been one of the world's best-selling antidepressant drugs, as it has proven efficacy and relatively good tolerance, making it a first-line clinical medication.
· Pharmacokinetics: The oral absorption is slow but persistent, and it undergoes extensive liver metabolism. The active metabolite, desmethyl sertraline, has relatively weak activity.
5. Safety and Precautions
· Common side effects: These include nausea, diarrhea, indigestion, dry mouth, dizziness, drowsiness, insomnia, excessive sweating and sexual dysfunction. These side effects usually occur in the early stages of treatment and will gradually subside.
· Serious risks:
· Serotonin syndrome: This life-threatening condition can occur when used in combination with other drugs that also increase serotonin levels (such as MAOI, other SSRIs, tricyclics, etc.).
· Black box warning: Like other antidepressants, sertraline carries a black box warning from the FDA, indicating that in the early stages of treatment, it may increase the risk of suicidal thoughts and behaviors in children, adolescents and young adults (under the age of 24).
· Withdrawal syndrome: Abrupt discontinuation of the medication can lead to symptoms such as dizziness, abnormal sensations, anxiety, and restlessness. Therefore, it should be done under the guidance of a doctor and gradually reduced in dosage.
· Contraindications: It is prohibited to use in combination with monoamine oxidase inhibitors and requires a sufficient washout period.
Summary

CAS 52341-91-0, namely sertraline hydrochloride, is a highly important and widely used SSRI-type antidepressant and anti-anxiety drug. It works by increasing the level of serotonin in the brain and is mainly used to treat various mental disorders such as depression and obsessive-compulsive disorder. Although it is relatively safe, it must be used under the guidance and supervision of a doctor, and potential side effects and risks should be noted.