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Loperamide Hydrochloride 99% Powder Pharmacy 53179-11-6

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Unit Price:

$342-360/KG FOB

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CAS No.:

53179-11-6

Port:

shanghai

Packaging:

1kg per bag

Price valid (until):

2029-12-28

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Xi'an Lanshan Biotechnology Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

5 days

Qualification:

Main Products:

Tranexamic acid,Plant extracts,nmn,Alpha Arbutin,food additives,ecdysone

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Product Description
Seller Information
Inquiry History

Description

loperamide hydrochloride, which is a chemical substance that is white to white crystalline powder. In the field of medicine, it is an antidiarrheal drug that reduces the number of bowel movements and relieves diarrhea symptoms by inhibiting intestinal peristalsis and prolonging the residence time of intestinal contents. For example, in the treatment of non-specific diarrhea and diarrhea caused by irritable bowel syndrome and colitis, drugs containing loperamide hydrochloride may be used.

ECHEMI Editorial Reference

ChEBI: A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.
Solid
Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It is a member of piperidines, a monocarboxylic acid amide, a member of monochlorobenzenes and a tertiary alcohol. It is a conjugate base of a loperamide(1+).|One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.|Loperamide is an Opioid Agonist. The mechanism of action of loperamide is as an Opioid Agonist.|Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.|Loperamide is a synthetic agent chemically related to the opiates with anti-diarrheal properties. Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction of gastro-intestinal secretion produced by opioid receptor binding in the intestinal mucosa. (NCI04)|One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Basic Info

Product Name:

Loperamide

Other Name:

1-Piperidinebutanamide,4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide;Loperamide;ADL 2-1294

CAS No.:

53179-11-6

Molecular Formula:

C29H33ClN2O2

InChIKeys:

InChIKey=RDOIQAHITMMDAJ-UHFFFAOYSA-N

Molecular Weight:

477.04

Exact Mass:

477.04

EC Number:

258-416-5

UNII:

6X9OC3H4II

DSSTox ID:

DTXSID6045165

NCI Thesaurus Code:

C618

ATC Code:

A07DA03|A - Alimentary tract and metabolism

HScode:

29252000

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

43.8

XLogP3:

5.15 (est)

Appearance:

Solid

Density:

1.187g/cm3

Melting Point:

222.1

Boiling Point:

647.2ºC at 760 mmHg

Flash Point:

345.2ºC

Refractive Index:

1.6

Water Solubility:

H2O: Slight soluble ;In water, 405 mg/L at 25 deg C (est)

Storage Conditions:

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. /Loperamide hydrochloride/

Vapor Pressure:

7.91X10-16 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 6.93X10-19 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 9.41 (strongest basic); pKa2 13.96 (strongest acidic) (est) /Loperamide hydrochloride/

Collision Cross Section:

222.7 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Experimental Properties:

Crystals from isopropanol. MP: 222-223 °C. UV Max (0.1N HCl.2-propanol, 10.90 v/v): 253, 259, 265, 273 nm (epsilon 532, 648, 581, 233). Freely soluble in chloroform; slightly soluble in dilute acids; very slightly soluble in isopropyl alcohol. Solubility (g/100 mL): water (pH 7.1) 0.14; citrate-phosphate (pH 6.1) 0.008; methanol 28.6; ethanol 5.37; 2-propanol 1.11; dichloromethane 35.1; acetone 0.20; ethyl acetate 0.035; diethyl ether <0.001; hexane <0.001; toluene 0.001; N,N-dimethylformamide 10.2; tetrahydrofuran 0.32; 4-methyl-2-pentanone 0.02; propylene glycol 5.64; polyethylene glycol 400 1.40; dimethylsulfoxide 20.5; 2-butanone 0.18. pKa 8.66. Practically insoluble at physiological pH (0.002%). Stable, can be stored for several years under normal conditions; not hygroscopic; not affected by light /Loperamide hydrochloride/|Hydroxyl radical reaction rate constant = 1.38X10-10 cu cm/molecule-sec at 25 °C (est)

See More Loperamide Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Loperamide hydrochloride

See More Loperamide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Tranexamic acid,Plant extracts,nmn,Alpha Arbutin,food additives,ecdysone

Location:
Tsinghua Science and Technology Park, Keji 2nd Road, Yanta District, Xi'an City, Shaanxi Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2021

Company Certificates
- ISO9001
- FDA
Xi'an Lanshan Biotechnology Co., Ltd. is a leading Trader supplier of α-Arbutin, Supply Top Quality Hericium Erinaceus Extract Lions Mane Extract powder Polysaccharide 30% 50%, (±)-Lipoic acid based in Xi'an, Shaanxi, China. With a commitment to quality and customer satisfaction, Xi'an Lanshan Biotechnology Co., Ltd. has become a trusted name in the industry. Our product line includes a range of high-quality α-Arbutin, Supply Top Quality Hericium Erinaceus Extract Lions Mane Extract powder Polysaccharide 30% 50%, (±)-Lipoic acid, which are available at competitive prices. Xi'an Lanshan Biotechnology Co., Ltd. has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Loperamide Hydrochloride 99% Powder Pharmacy	0.5 KG	Oct 25, 2025

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Loperamide Hydrochloride 99% Powder Pharmacy 53179-11-6

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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