USP EP 100% HPCD(HYDROXYPROPYL-BETA-CYCLODEXTRIN) CAS 128446-35-5

HPCD More Info

Chemical Profile and Structural Characteristics

Hydroxypropyl-β-cyclodextrin (HPCD, CAS 128446-35-5) is a cyclic oligosaccharide derivative produced through the hydroxypropylation of β-cyclodextrin. This semi-synthetic compound consists of seven glucose units connected by α-1,4-glycosidic bonds, forming a truncated cone structure with a hydrophilic exterior and a hydrophobic internal cavity. The hydroxypropyl substitution significantly enhances the compound's water solubility and reduces nephrotoxicity compared to the parent β-cyclodextrin. It typically presents as a white or almost white, amorphous or crystalline powder with a molecular weight that varies based on the degree of substitution, typically ranging from 1,300 to 1,500 Da.

Functional Properties and Molecular Interactions

The compound demonstrates exceptional molecular encapsulation capabilities through the formation of inclusion complexes with appropriately sized hydrophobic molecules. This host-guest chemistry enables the solubilization, stabilization, and bioavailability enhancement of poorly water-soluble compounds. The hydroxypropyl groups create steric hindrance that prevents self-association and crystallization while maintaining the cavity's complexation efficiency. Additional functional properties include surface activity, the ability to reduce irritation and volatility of encapsulated substances, and modification of chemical reactivity through microenvironment effects. These characteristics make it particularly valuable for pharmaceutical, food, and cosmetic applications.

Pharmaceutical Applications and Formulation Uses

HPCD serves as a versatile excipient in pharmaceutical formulations, primarily functioning as a solubility enhancer for poorly water-soluble active ingredients including antifungal agents, anti-inflammatory drugs, and chemotherapeutic compounds. It finds application in parenteral formulations where it improves drug stability and reduces side effects, in oral dosage forms where it enhances bioavailability, and in topical preparations where it modifies release characteristics. The compound is also utilized in protein stabilization, as a cholesterol extraction agent in cellular research, and as a component in chromatographic separation methods. Regulatory approvals exist for specific pharmaceutical applications with established safety profiles.

Manufacturing Process and Quality Control

We produce HPCD through a controlled etherification process of β-cyclodextrin with propylene oxide under alkaline conditions, followed by extensive purification to remove reaction by-products and unreacted starting materials. The manufacturing process carefully controls the degree of substitution to ensure consistent complexation properties and physicochemical characteristics. Quality specifications include tests for identity by infrared spectroscopy, substitution degree by NMR, residual solvents, heavy metals, and microbial limits. Analytical methods employ size-exclusion chromatography for molecular weight distribution, HPLC for purity assessment, and titration methods for substitution degree quantification.

Safety Profile and Regulatory Status

The compound demonstrates an excellent safety profile with established acceptable daily intake levels for various applications. Parenteral administration requires specific purity grades with of endotoxins and microbiological contaminants. Regulatory approvals include pharmaceutical compendial status in USP/NF, EP, and JP, with GRAS designation for specific food applications. Appropriate handling precautions include dust control measures during industrial processing, with comprehensive toxicological data supporting its use in various pharmaceutical and consumer product formulations. Storage recommendations specify protection from moisture at controlled room temperature to maintain product stability and performance characteristics.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.