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API Cyclophosphamide

Name: API Cyclophosphamide
Brand: Hyper Chem
SKU: pr2511271690
Price: 30 USD
Availability: InStock

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CAS No.:

50-18-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-12-27

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Cyclophosphamide
CAS number	50-18-0
Description	Cyclophosphamide is a precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active ALDOPHOSPHAMIDE. It has been used in the treatment of LYMPHOMA and LEUKEMIA
Related CAS #	50-18-0 6055-19-2 (hydrate)
Synonym	Cyclophosphamide
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Cyclophosphamide More Info

Cyclophosphamide (CP) is a synthetic alkylating agent belonging to the nitrogen mustard class, widely used in oncology and immunology. Below is a concise, professional overview tailored for pharmaceutical/chemical trade scenarios:

1. Core Information

Chemical Formula: C₇H₁₅Cl₂N₂O₂P

CAS Number: 50-18-0

Molecular Weight: 261.09 g/mol

Physical Properties: White to off-white crystalline powder; soluble in water, ethanol, and acetone; stable under normal storage conditions.

2. Mechanism of Action

As a prodrug, it is activated by hepatic microsomal enzymes (e.g., cytochrome P450). The active metabolites (e.g., phosphoramide mustard) alkylate DNA strands, inducing cross-linking and inhibiting DNA replication/transcription. This mechanism exerts cytotoxic effects on rapidly dividing cells, including cancer cells and immune cells.

3. Key Applications

Oncology: First-line treatment for hematological malignancies (e.g., leukemia, lymphoma) and solid tumors (e.g., breast cancer, ovarian cancer, lung cancer).

Immunology: Used in immunosuppressive therapy for autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) and organ transplant rejection prophylaxis.

4. Specifications & Quality Standards

Purity: ≥98.0% (HPLC)

Related Substances: Complies with USP, EP, or CP standards (total impurities ≤2.0%)

Water Content: ≤0.5%

Heavy Metals: ≤10 ppm

Storage: Store in a sealed container at 2-8°C, protected from light and moisture.

5. Trade & Regulatory Notes

Classification: Hazard Class 6.1 (Toxic substance); UN Number 2811.

Export Requirements: Complies with international regulations (e.g., CITES if applicable) and destination country import permits (e.g., FDA, EMA certifications for pharmaceutical grade).

Packaging: 1kg/foil bag, 25kg/drum (food-grade HDPE), with moisture-proof and shock-proof design.

6. Safety & Handling

Hazards: May cause skin/eye irritation; toxic if inhaled or ingested; potential teratogenicity.

Precautions: Wear protective gloves, goggles, and a respirator during operation; avoid contact with incompatible substances (e.g., strong acids/bases).

Waste Disposal: Dispose of per local environmental regulations (hazardous waste treatment).

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Basic Info

Product Name:

Cyclophosphamide

Other Name:

2H-1,3,2-Oxazaphosphorin-2-amine,N,N-bis(2-chloroethyl)tetrahydro-,2-oxide;2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]tetrahydro-,2-oxide;B 518;NSC 26271;Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester;N,N-Bis(2-chloroethyl)-N′,O-propylenephosphoric acid ester diamide;N,N-Bis(β-chloroethyl)-N′,O-trimethylenephosphoric acid ester diamide;Cyclophosphamid;Cyclophosphamide;Cyclophosphan;Cyclophosphane;Cytoxan;Endoxan;Genoxal;Clafen;Cytophosphan;Claphene;Asta B 518;2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide;Procytox;Sendoxan;(±)-Cyclophosphamide;(RS)-Cyclophosphamide;Cyclostin;Cycloblastin;Neosar;Neosar (antineoplastic);Endoxanal;CP;Senduxan;Zyklophosphamid;NCI C04900;Endoxan R;Endoxan-Asta;Endoxana;Mitoxan;Endoxane;Enduxan;CB 4564;SK 20501;CPA;CY;Hexadrin;Cyclophosphamidum;CTX;Semdoxan;Revimmune;Ledoxan;Cytophosphane;Eldamide;Neophos;Cyphos;Cydoxan;Cycrame;Oncomide;Cyclocel;Cycloxan;60007-95-6;75526-90-8

CAS No.:

50-18-0

Molecular Formula:

C7H15Cl2N2O2P

InChIKeys:

InChIKey=CMSMOCZEIVJLDB-UHFFFAOYSA-N

Molecular Weight:

261.085961

Exact Mass:

261.09

EC Number:

200-015-4

HScode:

2934999090

Categories:

Hormones and the Endocrine System

Characteristics

PSA:

41.6

XLogP3:

0.63

Appearance:

Cyclophosphamide is a fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45°C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.

Density:

1.48 g/cm³

Melting Point:

49.5-53 °C

Boiling Point:

336°C

Flash Point:

113°C c.c.

Refractive Index:

1.506

Water Solubility:

H2O: soluble . 1-5 g/100 mL at 23 ºC

Storage Conditions:

Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.

Vapor Pressure:

Vapour pressure, Pa at 25°C: 0.006 (calculated)

Toxicity:

LD50 oral in rat: 100mg/kg

Odor:

Odorless

Taste:

Slightly bitter

See More Cyclophosphamide Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1B

Reproductive toxicity, Category 1A

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H340 May cause genetic defects H350 May cause cancer H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. See Chemical Dangers. Dry. Keep in the dark. Well closed.Cyclophosphamide should be preserved in tight containers, at a temperature between 2 & 32 deg C.

See More Cyclophosphamide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Brazil	Ciclofosfamida	1.00 KG	Mar 28, 2025
India	Cyclodextrin glucanotransferase	50 MT	May 19, 2024

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