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Factory Supply Pure 98% HPLC PRN-2246 SAR 442168 Tolebrutinib CAS 1971920-73-6

Name: Factory Supply Pure 98% HPLC PRN-2246 SAR 442168 Tolebrutinib CAS 1971920-73-6
Brand: HORLDEN
SKU: pr2511131526
Price: 600 USD
Availability: InStock

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CAS No.:

1971920-73-6

Grade:

Chemical Grade

Content:

99%

Port:

SHENZHEN

Brand:

HORLDEN

Packaging:

1g/bottle

Sample Available:

Yes

Price valid (until):

2025-12-13

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Xi'an Horlden Bio-Tech Co., Ltd

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide

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Product Details
Seller Information

Description

Product Name	Tolebrutinib
CAS NO.	1971920-73-6
Purity	99%
Molecular formula	C26H25N5O3
MOQ	1 g

(R)-1-(1-Acryloylpiperidi-3-yl)-4-amino-3-(4-phenoxypheny)-1H-imidazo[4,5-C]pyridin-2(3H)-one is a potent, selective, orally active, blood-brain barrier-crossing Bruton's tyrosine kinase (BTK) inhibitor with IC50 values of 0.4 and 0.7 nM in Ramos B cells and HMC microglia, respectively. Tolebrutinib has immunomodulatory effects on the central nervous system.

You can ask us for quotation and product information via Email, Phone, WhatsApp and other channels.

Email: rock@horlden.com
WhatsApp/ Signal: +86 18829283179

1.What's your payment terms?

Standard terms: T/T in advance. Also L/C at sight is acceptable for large amount.

2.What's your shipping time?

We have bulk in stock, which means we can ship it to you immediately.

3.How do you ensure the quality of your products?

Strict QC with 6 steps testing from raw material purchase to finished product.

4.How do you ship the order normally?

For large qty order,ship the goods by sea. For small qty order, by air or express. We supply optional express for you, including DHL, FEDEX,UPS,TXT,EMS,and so on.

5.What's your loading port?

Usually Beijing, Shanghai, Qingdao, Tianjin, Guangzhou

ECHEMI Editorial Reference

Tolebrutinib is an orally bioavailable, brain-penetrant, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK), with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, tolebrutinib is able to cross the blood-brain barrier and inhibits the activity of BTK both peripherally and in the central nervous system (CNS). This prevents the activation of the B-cell antigen receptor (BCR) signaling pathway, and the resulting immune activation and inflammation. The inhibition of BTK activity also prevents microglial inflammatory signaling in the CNS, and the resulting immune activation, neuroinflammation and neurodegeneration. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. In addition to B cells, BTK is also expressed in innate immune cells, including macrophages and microglia, and plays an important role in the regulation of microglial inflammatory signaling.

Certificates

Basic Info

Product Name:

Tolebrutinib

Other Name:

Tolebrutinib;1971920-73-6;c]pyridin-2-one;UNII-8CZ82ZYY9X;8CZ82ZYY9X;4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-(prop-2-;enoyl)piperidin-3-yl]-1,3-dihydro-2H-imidazo[4,5-;(R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one;4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one;PRN2246

CAS No.:

1971920-73-6

Molecular Formula:

C26H25N5O3

InChIKeys:

KOEUOFPEZFUWRF-LJQANCHMSA-N

Molecular Weight:

455.5

Exact Mass:

455.19573968

UNII:

8CZ82ZYY9X

NCI Thesaurus Code:

C173549

Categories:

Inhibitor Drugs

Seller Information

Business Type:
Trader

Main Products:
Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide

Location:
9th Floor, Room 923, Building 3, Shiyuan Daguan, Xingtai 1st Street, Chanba Ecological District, Xi'an City, Shaanxi Province

Payment Terms:
100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2015

Xi'an Horlden Bio-Tech Co., Ltd is committed to promoting health application products such as chemical daily necessities, APIs, pharmaceutical intermediates and Cosmetic raw materials.

We have established friendly business relationships with hundreds of customers from over 50 countries and regions. Our team is committed to providing customers with the highest quality products at reasonable prices and satisfactory service. For many years, our company has won the trust and favor of our customers with high-quality products, first-class services, and competitive prices.

We will create the highest quality and most stable supply channel for customers, adhering to the spirit of serving customers, relying on strong funds and good cooperation reputation in the industry, to provide customers with higher quality products and services. At the same time, we are willing to strengthen exchanges and sincere cooperation with domestic and foreign merchants to create a better future together. It is your best supplier.

Welcome to Xi'an Horlden Bio-Tech Co., Ltd!
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Product Name	Grade / Content	Price	Supplier Name	Details
Tolebrutinib, (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one	/		Changzhou Guiding Bio-tech. Co.,Ltd.	Inquiry

Factory Supply Pure 98% HPLC PRN-2246 SAR 442168 Tolebrutinib CAS 1971920-73-6

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