Bosentan 147536-97-8
147536-97-8
Food grade
99%
shenzhen
Flying
10g/1kg/ 10kg/ 25kg
2025-12-14
vitamin
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferencePale Yellow to Off-White SolidBosentan was introduced in the US as a twice-daily oral treatment for pulmonary arterial hypertension. It can be synthesized in five steps via condensation of diethyl (2- methoxyphenoxy)malonate with pyrimidine-2-carboxamidine to give the precursor of the symmetrical central dichloropyrimidine ring which is then successively treated with the potassium salt of 4-tert-butylbenzenesulfonamide and the sodium salt of ethylene gycol. Bosentan is the first endothelin
Solid
Bosentan is a sulfonamide, a member of pyrimidines and a primary alcohol. It has a role as an antihypertensive agent and an endothelin receptor antagonist.|Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.|Bosentan anhydrous is an Endothelin Receptor Antagonist. The mechanism of action of bosentan anhydrous is as an Endothelin Receptor Antagonist, and Cytochrome P450 3A Inducer, and Cytochrome P450 2C9 Inducer.|Bosentan is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Bosentan has been associated with serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury.|A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.Basic Info-
Product Name:
Bosentan
Other Name:Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-;4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]benzenesulfonamide;Bosentan;p-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide;Ro 47-0203;Ro 47-0203/039;Tracleer;Actelion;ACT 434964;174227-18-0
CAS No.:147536-97-8
Molecular Formula:C27H29N5O6S
InChIKeys:InChIKey=GJPICJJJRGTNOD-UHFFFAOYSA-N
Molecular Weight:551.61
Exact Mass:551.61
EC Number:1308068-626-2
UNII:XUL93R30K2
DSSTox ID:DTXSID7046627
ATC Code:C02KX01|C - Cardiovascular system
HScode:29350090
Categories:
Characteristics-
PSA:
154
XLogP3:3.7
Appearance:Pale Yellow to Off-White Solid
Density:1.325±0.06 g/cm3(Predicted)
Melting Point:107-110°C
Boiling Point:742.3±70.0 °C(Predicted)
Flash Point:402.8±35.7 °C
Refractive Index:1.607
Water Solubility:Poorly soluble in water (1.0 mg/100 ml) and in aqueous solutions at low pH (0.1 mg/100 ml at pH 1.1 and 4.0; 0.2 mg/100 ml at pH 5.0). Solubility increases at higher pH values (43 mg/100 ml at pH 7.5).
Storage Conditions:-20°C Freezer
Vapor Pressure:0mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
H412 Harmful to aquatic life with long lasting effects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
