PNC-27 CAS: 1159861-00-3 Anti-cancer peptide, used for cancer treatment, factory supply, with favorable price.

Name: Luna
Whatsapp/WeChat: +86 18617657867
Email: luna@duole-tech.com

PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.

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The importance of peptides

Many active substances in the human body are in the form of peptides. Peptides are involved in various fields of human hormones, nerves, cell growth and reproduction, and their importance is to regulate the physiological functions of various systems and cells in the body, activate the relevant enzyme systems in the body, promote the permeability of intermediate metabolic membranes, or control DNA transcription or affect specific protein synthesis, and ultimately produce specific physiological effects. Peptides are important substances involved in various cell functions in human body. Peptides can be synthesized into cells and regulate their functional activities. Peptides act as neurotransmitters in the body, transmitting information. Peptides can be used as transportation tools in the human body to transport various nutrients and various vitamins, biotin, calcium and trace elements beneficial to the human body to the cells, organs and tissues of the human body. Peptide is an important physiological regulator of the human body, which can comprehensively regulate the physiological function of the human body, enhance and exert the physiological activity of the human body, and it has important biological functions.

1. Any inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4.  Reasonable & competitive price, fast lead time.

5. High quality with competitive price.

6. All purity>99%.

Q1: How can I contact you?

A: Contact us via email or Whatsapp/telegram.

Q2: How to send order?

A: Send order list to us, we quote best price for you, then ship package out and offer tracking nubmer to you after payment send.

Q3: How to confirm the product quality before placing an order?

A: You can get some samples of products.  You can also send us the specifications or your requirements, and we will customize the product for you.

Q4: Do you have samples for our reference?

A: Sure, we can offer free samples, the customers will pay the freight.

Q5: Any discount if order more?

A: Sure, the price is negotiable, you can get much better price if order big quantity.

Q6: Is there any possible to use my appointed label or package?

A: Yes. If needed, we'd like to use label or package according to your requirement.

Q 7 : How to preserve peptides after receiving them?

A: Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2 ° C - 8 ° C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20 ° C or -80 ° C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.

Q 8 : What is your MOQ?

A: The minimum quantity we can order is 1 box.