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4-Iodophenol CAS:540-38-5

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CAS No.:

540-38-5

Grade:

Industrial Grade

Content:

99%

Port:

SHANGAHI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

4-Iodophenol Basic information

Product Name:	4-Iodophenol
Synonyms:	4-hydroxyiodobenzene;4-hydroxyphenyliodide;4-iodo-pheno;Phenol, p-iodo-;p-hydroxyiodobenzene;p-iodo-pheno;I**4-Iodophenol;P-IODOPHENOL
CAS:	540-38-5
MF:	C6H5IO
MW:	220.01
EINECS:	208-745-5
Product Categories:	Pyridines;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Heterocyclic Compounds;Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:	540-38-5.mol

4-Iodophenol Chemical Properties

Melting point	92-94 °C(lit.)
Boiling point	138 °C5 mm Hg(lit.)
density	1.8573
Fp	138°C/5mm
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	9.33(at 25℃)
form	Crystals or Crystalline Powder
color	Pink or beige to brown
Water Solubility	slightly soluble
Sensitive	Light Sensitive
Merck	14,5036
BRN	1904544
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	540-38-5(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 4-iodo-(540-38-5)
EPA Substance Registry System	p-Iodophenol (540-38-5)

Safety Information

Hazard Codes	C,Xi,Xn
Risk Statements	21/22-34-36/37/38-20/21/22
Safety Statements	26-36/37/39-45-22
RIDADR	UN 3261 8/PG 3
WGK Germany	3
RTECS	SL5600000
Hazard Note	Irritant
TSCA	T
HazardClass	IRRITANT, LACHRYMATOR
HS Code	29081900

4-Iodophenol Usage And Synthesis

Chemical Properties	Light brown powder. It dissolves slightly in water, but readily dissolves in ethanol, ether, and other organic solvents.
Uses	4-Iodophenol is used in chemiluminescence imaging assays and experiments, as diagnostic agents in order to detect cancer cells in patients. It is also utilized in synthesizing agonists for the estrogen β receptor. Additionally, The compound finds extensive applications in various medical industries as well as in human and animal nutrition products such as pharmaceutical intermediates, and polarizing films for Liquid Crystal Display (LCD) chemicals.
Definition	ChEBI: 4-iodophenol is an iodophenol.
Preparation	It is obtained from 4-Aminophenol by diazotisation and substitution.
Application	4-Iodophenol can be used as a building block for the synthesis of: Hydroxybiaryls by reacting with aryl boronic acids via Pd-catalyzed Suzuki-Miyaura coupling reaction.[1][2] Aryl substituted olefins by reacting with acrylates via Pd-catalyzed Heck reaction.[3] Iodinated-4-aryloxymethylcoumarins [4] Hydroxylated stilbenoids [5] and psammaplysenes A and B.[6]
Synthesis Reference(s)	Organic Syntheses, Coll. Vol. 2, p. 355, 1943 The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x Tetrahedron Letters, 40, p. 6051, 1999 DOI: 10.1016/S0040-4039(99)01236-8
Metabolism	4-Iodophenol has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(4-iodophenoxy)oxane-2-carboxylic acid.
Purification Methods	Crystallise 4-iodophenol from pet ether (b 80-100o) or distil it in vacuo. If the material has a brown or violet color, then dissolve it in CHCl3, shake it with 5% sodium thiosulfate solution until is colourless. Dry (Na2SO4), extract, evaporate and disil the residue in vacuo. [Dains & Eberly Org Synth Coll Vol II 355 1948, Beilstein 6 IV 1074.]
References	[1] HIDEHIRO SAKURAI Toshikazu H Tatsuya Tsukuda. Pd/C as a Reusable Catalyst for the Coupling Reaction of Halophenols and Arylboronic Acids in Aqueous Media[J]. The Journal of Organic Chemistry, 2002, 67 8: 2721-2722. DOI:10.1021/jo016342k. [2] PIOTR WAWRZYNIAK Joachim H. Microwave-Promoted Suzuki—Miyaura Coupling of Arylboronic Acids with 1-Bromo-2-naphthol, o-Bromophenol, and o-Chlorophenol.[J]. ChemInform, 2007, 38 14. DOI:10.1002/chin.200714105. [3] LUNXIANG YIN Juergen L. Carbon—Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts[J]. ChemInform, 2007, 38 22. DOI:10.1002/chin.200722237. [4] MAHANTESHA BASANAGOUDA . Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents[J]. European Journal of Medicinal Chemistry, 2014, 74: Pages 225-233. DOI:10.1016/j.ejmech.2013.12.061. [5] AMIT SHARD. Tandem Heck/Decarboxylation/Heck Strategy: Protecting-Group-Free Synthesis of Symmetric and Unsymmetric Hydroxylated Stilbenoids?[J]. Angewandte Chemie International Edition, 2012, 51 49: 12250-12253. DOI:10.1002/anie.201206346. [6] SAVVAS N. GEORGIADES Jon C. Total Synthesis of Psammaplysenes A and B, Naturally Occurring Inhibitors of FOXO1a Nuclear Export[J]. Organic Letters, 2005, 7 19: 4091-4094. DOI:10.1021/ol0513286.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

4-Iodophenol

Other Name:

Phenol,4-iodo-;Phenol,p-iodo-;4-Iodophenol;p-Iodophenol;4-Hydroxyiodobenzene;4-Hydroxyphenyl iodide;p-Hydroxyiodobenzene;NSC 91464;1-Iodo-4-hydroxybenzene;1779540-31-6

CAS No.:

540-38-5

Molecular Formula:

C6H5IO

InChIKeys:

InChIKey=VSMDINRNYYEDRN-UHFFFAOYSA-N

Molecular Weight:

220.01

Exact Mass:

220.01

BRN:

1904544

EC Number:

208-745-5

UNII:

BH194BAK0B

NSC Number:

91464

DSSTox ID:

DTXSID4052186

HScode:

29081900

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

20.2

XLogP3:

2.91

Appearance:

Pink or beige to brown Crystals or Crystalline Powder

Density:

2.0±0.1 g/cm3

Melting Point:

93.5 °C

Boiling Point:

138 °C5 mm Hg(lit.)

Flash Point:

138°C/5mm

Refractive Index:

1.669

Water Solubility:

H2O: slightly soluble

Toxicity:

Peritoneal-mouse LD50: 700 mg/kg

Flammability characteristics:

Open flame

See More 4-Iodophenol Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin corrosion, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-Iodophenol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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