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Chlorotrimethylsilane CAS:75-77-4

Name: Chlorotrimethylsilane CAS:75-77-4
Brand: Orient
SKU: pr2511261456
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CAS No.:

75-77-4

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2025-12-26

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Trader

Location:

China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Inquiry History

Description

Items	Specifications
Product name	Chlorotrimethylsilane
CAS	75-77-4
Appearance	LIQUID
Uses	Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
Application	Trimethylsilyl chloride(TMCS) is the most extensively used derivatization reagent for gas chromatography.The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples.There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones.The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.TMCS is included as a catalyst with other trialkylsilyl reagent such N,O-bis- (trimethylsilyl)trifluroacetamide (BSA) or N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA).The order of functional group reactivity is alcohols>phenols>carboxylic acids>amines>amides.
Reactions	Related to the epoxide ring opening, TMSCl also mediates some cyclopropane ring opening reactions. For example, treatment of 1-aceto-2,2-dimethylcyclopropane with TMSCl and sodium chloride in acetonitrile at 55°C for 24 h generated 5-chloro-5-methyl-2-hexanone in 84% yield (eq 39).When sodium iodide was employed to replace sodium chloride, iodotrimethylsilane generated in situ, and the reaction completed under more facile conditions (rt and 12 h). Interestingly, the dominant product is 5-iodo-4,4-dimethyl-2-pentanone (eq 40), arising from iodide attacking at the less hindered secondary methylene carbon, instead of the quaternary dimethylmethylene carbon.
General Description	Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854g/cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

Chlorotrimethylsilane Chemical Properties

Melting point	−40 °C(lit.)
Boiling point	57 °C(lit.)
density	0.857 g/mL at 25 °C
vapor density	3.7 (vs air)
vapor pressure	100 mm Hg ( 25 °C)
refractive index	n20/D 1.500
Fp	104 °F
storage temp.	Store below +30°C.
solubility	Miscible with ether, benzene, diethylether and perchloroethylene.
form	Liquid
Specific Gravity	0.8536 (27℃)
color	Clear colorless
explosive limit	1.5-46%(V)
Water Solubility	REACTS
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	1209232
Stability:	Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
InChIKey	IJOOHPMOJXWVHK-UHFFFAOYSA-N
CAS DataBase Reference	75-77-4(CAS DataBase Reference)
NIST Chemistry Reference	Silane, chlorotrimethyl-(75-77-4)
EPA Substance Registry System	Trimethylchlorosilane (75-77-4)

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Certificates

Basic Info

Product Name:

Chlorotrimethylsilane

Other Name:

Silane,chlorotrimethyl-;Chlorotrimethylsilane;Trimethylchlorosilane;Trimethylsilyl chloride;Trimethylsilicon chloride;Monochlorotrimethylsilicon;Trimethylsilane chloride;TSL 8031;Monochlorotrimethylsilane;KA 31;KA 31 (silane);NSC 15750;TMCS;LS 260;TMSCl;127290-36-2;36642-33-8

CAS No.:

75-77-4

Molecular Formula:

C3H9ClSi

InChIKeys:

InChIKey=IJOOHPMOJXWVHK-UHFFFAOYSA-N

Molecular Weight:

108.64200

Exact Mass:

108.64

EC Number:

200-900-5

UNII:

62UO4690X6

ICSC Number:

0966

NSC Number:

15750

UN Number:

1298

DSSTox ID:

DTXSID2024822

Color/Form:

Colorless liquid

HScode:

29310095

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

2.06010

Appearance:

Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

Density:

0.854 g/cm³ @ Temp: 25 °C

Melting Point:

-57.7 °C

Boiling Point:

57 °C

Flash Point:

-18ºC

Refractive Index:

1.387-1.389

Water Solubility:

Solubility in water: reaction

Storage Conditions:

Store at RT.

Vapor Pressure:

100 mm Hg ( 25 °C)

Vapor Density:

3.7 (vs air)

Toxicity:

LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg

Flammability characteristics:

LOWER 1.8%

Explosive limit:

vol% in air: 1.8

Odor:

SHARP, HYDROCHLORIC ACID-LIKE ODOR; ACRID.

Experimental Properties:

Ratio of specific heats of vapor (gas): 1.0683. (est)|Readily hydrolyzed with liberation of hydrochloric acid|Organo-functional silanes are noted for their ability to bond organic polymer systems to inorganic substrates /Silane cmpd/|The reaction of organosilanes with halogens and halogen cmpd usually proceeds in good yield through cleavage of the Si--H bond and formation of the silicon-halogen bond. Reaction with fluorine, however, does not proceed satisfactorily because of cleavage of not only the Si--H but also C--Si and C--H bonds. Direct halogenation with chlorination, bromine, and iodine proceeds smoothly, however. /Organosilanes/|Hydroxyl radical reaction rate constant = 4.49X10-13 cu cm/molec sec at 25 °C (est)

Air and Water Reactions:

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water. Products of the reaction include hydrogen chloride. The heat may be sufficient to ignite nearby combustible materials. Trimethylchlorosilane reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 1.3 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Reactive Group:

Chlorosilanes

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

TRIMETHYLCHLOROSILANE reacts vigorously and exothermically with water to produce hydrogen chloride.

Autoignition Temperature:

743 °F (USCG, 1999)|743 °F (395 °C)|395 °C

Heat of Combustion:

-10,300 BTU/LB (EST)

Flammable Limits:

Lower flammable limit: 1.8% by volume; Upper flammable limit: 6.0% by volume|LOWER 1.8%

Physical Dangers:

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Heat of Vaporization:

126 BTU/LB

See More Chlorotrimethylsilane Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Acute toxicity - Category 3, Oral

Acute toxicity - Category 4, Dermal

Skin corrosion, Sub-category 1A

Acute toxicity - Category 3, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H301 Toxic if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H331 Toxic if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from food and feedstuffs and other compounds. Cool. Dry. Well closed.Storage temperature; ambient.

See More Chlorotrimethylsilane Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	TMCS Trimethylchlorosilane	1 MT	Jan 14, 2026
India	Chlorotrimethylsilane 99% powder or vials/Liquid or oily/Crystal or Ointment Chlorotrimethylsilane	1 MT	Jun 30, 2023
Romania	Trimethylchlorosilane	680 KG	Sep 30, 2025

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Chlorotrimethylsilane CAS:75-77-4

Product Description

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