Chlorotrimethylsilane

108.64200

108.64

200-900-5

62UO4690X6

0966

15750

1298

DTXSID2024822

Colorless liquid

29310095

0

2.06010

Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135° F, Flash point -18°F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

0.854 g/cm³ @ Temp: 25 °C

-57.7 °C

57 °C

-18ºC

1.387-1.389

Solubility in water: reaction

Store at RT.

100 mm Hg ( 25 °C)

3.7 (vs air)

LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg

LOWER 1.8%

vol% in air: 1.8

SHARP, HYDROCHLORIC ACID-LIKE ODOR; ACRID.

Ratio of specific heats of vapor (gas): 1.0683. (est)|Readily hydrolyzed with liberation of hydrochloric acid|Organo-functional silanes are noted for their ability to bond organic polymer systems to inorganic substrates /Silane cmpd/|The reaction of organosilanes with halogens and halogen cmpd usually proceeds in good yield through cleavage of the Si--H bond and formation of the silicon-halogen bond. Reaction with fluorine, however, does not proceed satisfactorily because of cleavage of not only the Si--H but also C--Si and C--H bonds. Direct halogenation with chlorination, bromine, and iodine proceeds smoothly, however. /Organosilanes/|Hydroxyl radical reaction rate constant = 4.49X10-13 cu cm/molec sec at 25 °C (est)

Highly flammable. Fumes in air. Reacts vigorously and exothermically with water. Products of the reaction include hydrogen chloride. The heat may be sufficient to ignite nearby combustible materials. Trimethylchlorosilane reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 1.3 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Chlorosilanes

Highly Flammable

TRIMETHYLCHLOROSILANE reacts vigorously and exothermically with water to produce hydrogen chloride.

743 °F (USCG, 1999)|743 °F (395 °C)|395 °C

-10,300 BTU/LB (EST)

Lower flammable limit: 1.8% by volume; Upper flammable limit: 6.0% by volume|LOWER 1.8%

The vapour is heavier than air and may travel along the ground; distant ignition possible.

126 BTU/LB

II

3

UN 1298

2

R11; R14; R21; R34

S16-S26-S36/37/39-S45

VV2710000

C

Fireproof. Separated from food and feedstuffs and other compounds. Cool. Dry. Well closed.

Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.

P210-P261-P280-P301 + P310-P305 + P351 + P338-P310

H225-H301 + H331-H312-H314

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Reacts with surface moisture to evolve hydrogen chloride, which will corrode common metals & form flammable hydrogen gas.|... They will react with water or steam to produce heat, toxic & corrosive fumes of hydrochloric acid. /Chlorosilanes/|Interaction of the lithium derivative /eg hexafluoroisopropylideneaminolithium/ with a range of chloro- and fluoro-derivatives of arsenic, boron, phosphorus, silicon and sulfur during warming to 25 °C tended to be violently exothermic in absence of solvent ...|Silane and chlorosilanes can explode when mixed with various halocarbons and ignited.|... Reacts violently with alcohols, amines causing fire and explosion hazard. Attacks many metals in presence of water.

European Chemicals Bureau; IUCLID Dataset, Chlorotrimethylsilane. (75-77-4) (2000 CD-ROM edition). Information on usage patterns, toxicology, and environmental effects provided by industry to the European Union. Available from the database query page: http://ecb.jrc.it/esis/esis.php as of October 16, 2006.|Health Council of the Netherlands: Dutch Expert Committee on Occupational Standards. Chlorotrimethylsilane; Health-based recommended occupational exposure limit. 62 p. The Hague: Health Council of the Netherlands, 2001; publication no. 2001/05OSH. The Health Council of the Netherlands recommends health-based occupational exposure limits for the concentration of toxic substances in air at the workplace. These recommendations are made by the Council's Dutch Expert Committee on Occupational Standards. They constitute the first step in a three-step procedure that leads to legally-binding limit values. The present report on chlorotrimethylsilane was prepared in co-operation with the Nordic Expert Group, wich advises the Nordic Governments. ... The committee's conclusions are based on scientific publications prior to March 1998.|USEPA; Chemical Profile: Triemethylchlorosilane (1985). Aspects covered in this data sheet: exposure limitations; personal protective equipment; fire hazards; fire fighting; disposal; first aid; spills.

UN 1298

P210; P260; P280; P305 + P351 + P338; P370 + P378; P403 + P235

Violent reaction with water. Toxic and irritating hydrogen chloride and phosgene may be formed in fires. Difficult to extinguish, re-ignition may occur. Flashback along vapor trail may occur. Containers may explode in fire. Vapor may explode if ignited in enclosed area. When heated to decomposition or on contact with acids or acid fumes, chloride fumes are emitted. Reacts with surface moisture, releasing hydrogen chloride, which will corrode common metals and form flammable hydrogen gas. Avoid contact with water; it readily hydrolyzes, liberating hydrochloric acid. Hazardous polymerization may not occur. (EPA, 1998)|Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.|Corrosives, Flammable - 3rd degree, Reactive - 2nd degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P311, P312, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 2495 companies from 26 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P310, P311, P312, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1298 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 155 [Substances - Toxic and/or Corrosive (Flammable / Water-Sensitive)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor-suppressing foam may be used to reduce vapors. FOR CHLOROSILANES, use AFFF alcohol-resistant medium-expansion foam to reduce vapors. DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. (ERG, 2016)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|... Prevent, from outset, any planned or accidental contact with corrosive substances by utilizing only closed-circuit apparatus ... /otherwise/ corrosion-resistant & impervious suits or overalls, foot, ... hand & arm, ... head, ... eye & face protection ... /should be relied on/. /Corrosive substances/|... Where aprons are used ... these should have bibs; sleeves should be worn outside ... gloves, and ... trouser legs should cover tops of shoes ... When exposure ... is not severe ... barrier creams can often be used instead of gloves. /Corrosive substances/|Acid-vapor-type respiratory protection; rubber gloves; chemical worker's goggles; other protective equipment as necessary to protect skin and eyes.|Face shield, or eye protection in combination with breathing protection.

A flammable liquid and very dangerous fire haszard when exposed to heat or flame.|Contact with water applied to adjacent fires produces irritating hydrogen chloride.|Flammable liquid

Containers may explode in fire. ... Vapor may explode if ignited in enclosed area.|Lower limit: 1.8% by volume; Upper limit: 6.0% by volume|Explosive limits , vol% in air: 1.8-6

Aqueous film forming foam (AFFF), carbon dioxide, dry sand, special powder. NO hydrous agents. NO water.|If material on fire or involved in fire: Do not extinguish the fire unless flow can be stopped. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.

Flashback along vapor trail may occur.|Behavior in fire: difficult to extinguish; re-ignition may occur.|The vapor is heavier than air and may travel along the ground; distant ignition possible ... Reacts violently with fire extinguishing agents such as water.

Shut off ignition sources. Call fire department. Avoid contact with liquid. Keep people away. Stop discharge if possible. Isolate and remove discharged material. Notify local health and pollution control agencies.|Flush with water. Rinse with sodium bicarbonate or lime soln.|Evacuate danger area! Consult an expert! Collect leaking liquid in sealable dry containers; do not use plastic containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus.)

It is good practice to install emergency showers at all strategic locations; these should ... be actuated automatically by pressure on foot plate; bath tubs filled with clean water can also provide valuable service in ... emergency. /Corrosive substances/|CAUTION: Silanes are toxic. Avoid contact with skin and eyes. Use effective fume removal device. /Silanes/|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|For more Preventive Measures (Complete) data for TRIMETHYLCHLOROSILANE (8 total), please visit the HSDB record page.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY.|Table of Water-Reactive Materials Which Produce Toxic Gases. Trimethylchlorosilane|/GUIDE 155: SUBSTANCES - TOXIC and/or CORROSIVE (Flammable/Water-Sensitive)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.|/GUIDE 155: SUBSTANCES - TOXIC and/or CORROSIVE (Flammable/Water-Sensitive)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|For more DOT Emergency Guidelines (Complete) data for TRIMETHYLCHLOROSILANE (10 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Strong irritant to tissue.|Irritating to the skin, eyes and mucous membrane. /Chlorosilanes/|... /Trimethylchlorosilane/ and the vapor are corrosive to the eyes, the skin and the respiratory tract ... Inhalation of the vapor may cause lung edema ...

Evacuate danger area! Consult an expert! Collect leaking and spilled liquid in sealable dry non-plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Personal protection: complete protective clothing including self-contained breathing apparatus.

Fireproof. Separated from food and feedstuffs and other compounds. Cool. Dry. Well closed.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Exposure could cause death. Medical observation is indicated.

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.

STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures.|W - No water: Materials that react violently or explosively with water.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Trimethylchlorosilane is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 1,000 lbs.

LD50 Rabbit dermal 1780 uL/kg|LD50 Rabbit dermal 1500 mg/kg|LD50 Rabbit (female) dermal 1.78 (95% confidential limit 0.84 to 3.79) mL/kg|LD50 Rabbit (male) dermal 2.83 (95% confidential limit 1.56 to 3.63) mL/kg|For more Non-Human Toxicity Values (Complete) data for TRIMETHYLCHLOROSILANE (9 total), please visit the HSDB record page.

Trimethylchlorosilane's production and use as an intermediate in silicone synthesis as well as use as a chain terminating agent and imparting water repellence(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Trimethylchlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).|AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylchlorosilane, which has a vapor pressure of 234 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethylchlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

The rate constant for the vapor-phase reaction of trimethylchlorosilane with photochemically-produced hydroxyl radicals has been estimated as 4.5X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 12 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). All silicon chlorides are immediately and completely hydrolyzed by water(2) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

Trimethylchlorosilane has been reported to hydrolyze immediately upon contact with water(1) and therefore bioconcentration of trimethylchlorosilane is not expected(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylcholorsilane is expected to occur more rapidly than adsorption(SRC).

All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Decomposition of trimethylchlorosilane is expected to occur more rapidly than volatilization(SRC.) Trimethylchlorosilane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,876 workers (20 of these are female) are potentially exposed to trimethylchlorosilane in the US(1). Occupational exposure to trimethylchlorosilane may occur through inhalation and dermal contact with this compound at workplaces where trimethylchlorosilane is produced or used(SRC).

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)

... Absorption through the skin can be expected ... /and/ is supported by the findings from an acute dermal toxicity study ... although the corrosive nature of chlorotrimethylsilane may have enhanced dermal penetration by breaking down normal barriers.|The substance can be absorbed into the body by inhalation of its vapor and by ingestion.

Chlorotrimethylsilane will be rapidly hydrolyzed upon contact with tissue fluid releasing hydrogen chloride and trimethylsilanol which condenses to form hexamethyldisiloxane and water ... Trimethylsilanol /is considered/ to be a stable compound that will not be metabolized to a great extent. In view of the rapid hydrolysis in aqueous environments, it is obvious that toxicokinetic studies, even at low concentrations, are difficult to carry out.|... Chlorosilanes will be rapidly hydrolyzed upon contact with tissue fluids to release hydrochloric acid. /Chlorosilanes/

Similar to other silanes. Toxicity is rated high for inhalation, ingestion and local irritation. May cause death or permanent injury after a very short exposure to small quantities. (EPA, 1998)

Warning: In the presence of water, trimethylchlorosilane liberates hydrochloric acid, which is extremely corrosive. Caution is advised. Signs and Symptoms of Acute Trimethylchlorosilane Exposure: Signs and symptoms of acute trimethylchlorosilane exposure may include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. Vomitus generally has a coffee-ground appearance. Acute inhalation exposure may result in hoarseness, laryngitis, a feeling of suffocation, dyspnea (shortness of breath), choking, respiratory tract irritation, chest pain, and pulmonary edema. The potential for circulatory collapse is high following ingestion of trimethylchlorosilane. Sneezing, bleeding of the nose and gums, and ulceration of the nasal and oral mucosa may also occur. Renal toxicity has been observed in animals. If the eyes come in contact with trimethylchlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermal exposure is generally followed by dermatitis (red, inflamed skin), severe burns, pain, and shock. Emergency Life-Support Procedures: Acute exposure to trimethylchlorosilane may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to trimethylchlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to trimethylchlorosilane. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas THOROUGHLY with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Rinse mouth with large amounts of water. Inform victims not to swallow this water. 3. DO NOT induce vomiting or attempt to neutralize! 4 Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 5. Activated charcoal is of no value. 6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 7. RUSH to a health care facility. (EPA, 1998)

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

No specific antidote is available /for chlorosilanes/, but first aid treatment consists of copious irrigation with water, & subsequent treatment is as for chemical burns in general. /Chlorosilanes/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/|FIRST AID: Inhalation--Fresh air, rest. Half-upright position. Artificial respiration may be needed ... The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered ... Skin--Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention; Eyes--First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor; Ingestion--Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention.

/SIGNS AND SYMPTOMS/ Inhalation of vapor irritates mucous membranes. Contact of liq with eyes or skin causes severe burns. Ingestion causes severe burns of mouth and stomach. ... Vapors cause severe irritation of ... throat and can cause ... lung injury.|/SIGNS AND SYMPTOMS/ ... Chlorotrimethylsilane is a very irritative compound, probably due to its very fast hydrolysis to hydrogen chloride. ... Severe irritation of skin, eyes (from exposure to the liquid), and mucous membranes (by vapors), and severe burns of mouth and stomach following ingestion were mentioned.|/SIGNS AND SYMPTOMS/ ... /Trimethylchlorosilane/ and the vapor are corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapor may cause lung edema ... The symptoms of lung edema often do not become manifest until a few hours have passed and they are aggravated by physical effort ... Exposure may result in death ...|/SIGNS AND SYMPTOMS/ ACUTE ... SYMPTOMS: Inhalation--Burning sensation. Cough. Sore throat. Labored breathing. Shortness of breath. Symptoms may be delayed ... Skin--Redness. Pain. Blisters. Skin burns; Eyes--Redness. Pain. Severe deep burns; Ingestion--Burning sensation. Abdominal pain. Shock or collapse.

chlorotrimethylsilane

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Burning sensation. Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. Blisters. Skin burns.

Redness. Pain. Severe deep burns.

GRADES OF PURITY: 98+%.

All other basic inorganic chemical manufacturing|Silane, chlorotrimethyl-: ACTIVE|The high reactivity means it must be manufactured, stored, and used in airtight specialized installations. The entire production is used for the manufacture of organosilicic derivatives, mainly polysiloxanes ...|Antimony trichloride-catalyzed chlorination of the silane to chlorotrimethylsilane in absence of diluent was explosive at 100 °C, but controllable at below 30 °C.

Fire Hazards -> Corrosives, Flammable - 3rd degree, Reactive - 2nd degree