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6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 2240-25-7

Name: 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 2240-25-7
Brand: Orient
SKU: pr2511271859
Price: 4 USD
Availability: InStock

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CAS No.:

2240-25-7

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-27

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Basic information

Product Name:	6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
Synonyms:	5-BROMOCYTOSINE;6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE;TIMTEC-BB SBB000280;2(1H)-Pyrimidinone, 4-amino-5-bromo-;4-amino-5-bromo-2(1h)-pyrimidinon;4-Amino-5-bromo-2(1H)-pyrimidinone;4-Amino-5-bromo-2-hydroxypyrimidine;5-BROMOCYTOSINE CRYSTALLINE
CAS:	2240-25-7
MF:	C4H4BrN3O
MW:	190
EINECS:	218-806-8
Product Categories:
Mol File:	2240-25-7.mol

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Chemical Properties

Melting point	240-243 °C (dec.) (lit.)
density	1.7513 (rough estimate)
refractive index	1.6520 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in formic acid (50 mg/ml).
pka	7.34±0.10(Predicted)
form	Solid
color	White to yellow
BRN	127286
InChI	InChI=1S/C4H4BrN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
InChIKey	QFVKLKDEXOWFSL-UHFFFAOYSA-N
SMILES	C1(=O)NC(N)=C(Br)C=N1
NIST Chemistry Reference	5-Bromocytosine(2240-25-7)

Safety Information

Hazard Codes	Xn
Risk Statements	22-37/38-41-43-48-20/21/22
Safety Statements	24/25-22-36/37/39-26-45-7/8
WGK Germany	3
F	10-23
HS Code	29335990

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Usage And Synthesis

Chemical Properties	LIGHT YELLOW AMORPHOUS POWDER
Uses	4-Amino-5-bromo-2-hydroxypyrimidine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.
Uses	5-Bromocytosine was used in the synthesis of five cross-link products- C[5-N6]A, C[5-2]A, C[5-8]A, A[2-5]C, and A[8-5]C, under both aerobic and anaerobic conditions.
General Description	5-Bromocytosine derivative (β isomer) is a potent anti-HIV agent.
Synthesis	71-30-7 2240-25-7 General procedure for the synthesis of 4-amino-5-bromopyrimidin-2(1H)-one from 6-aminopyrimidin-2(1H)-one: 6-aminopyrimidin-2(1H)-one (55.6 g, 0.5 mol), N-bromosuccinimide (106.8 g, 0.6 mol) and DMF (150 mL) were added to a reaction flask, cooled to 15°C, and ultrasonicated for reaction under ultrasonic condition for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete reaction of the raw materials, it was filtered. The filter cake was washed with distilled water (20 mL×2) and dried to obtain 4-amino-5-bromopyrimidin-2(1H)-one (90.9 g, 95.6% yield).
Purification Methods	5-Bromocytosine is recrystallised from H2O or 50% aqueous EtOH. Alternatively, dissolve ca 3g in conc HCl (10mL) and evaporate to dryness. Dissolve the residual hydrochloride in the minimum volume of warm H2O and make faintly alkaline with aqueous NH3. Collect the crystals and dry them in a vacuum at 100o. [Hilbdert & Jensen J Am Chem Soc 56 134 1934, Beilstein 25 III/IV 3689.]
References	[1] Patent: CN103819412, 2016, B. Location in patent: Paragraph 0023-0025; 0031-0032; 0037; 0038 [2] Synthesis, 2005, # 7, p. 1103 - 1108 [3] Tetrahedron Letters, 1992, vol. 33, # 50, p. 7779 - 7782 [4] Chemistry Letters, 1987, p. 2311 - 2312 [5] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 11, p. 3750 - 3751

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Bromine-->Cytosine-->N-Bromosuccinimide-->N,N-Dimethylformamide

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

5-Bromocytosine

Other Name:

2(1H)-Pyrimidinone,6-amino-5-bromo-;Cytosine,5-bromo-;2(1H)-Pyrimidinone,4-amino-5-bromo-;6-Amino-5-bromo-2(1H)-pyrimidinone;5-Bromocytosine;4-Amino-5-bromo-2-hydroxypyrimidine;31295-39-3

CAS No.:

2240-25-7

Molecular Formula:

C4H4BrN3O

InChIKeys:

InChIKey=QFVKLKDEXOWFSL-UHFFFAOYSA-N

Molecular Weight:

190

Exact Mass:

190.00

EC Number:

218-806-8

UNII:

2737MSZ714

DSSTox ID:

DTXSID60176932

HScode:

2933599090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

67.5

XLogP3:

-0.3

Appearance:

White to yellow Solid

Density:

1.3±0.1 g/cm3

Melting Point:

245-255 °C (decomp)

Flash Point:

171.2±27.9 °C

Refractive Index:

1.583

Water Solubility:

Soluble in formic acid (50 mg/ml).

See More 5-Bromocytosine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Skin sensitization, Category 1

Serious eye damage, Category 1

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H318 Causes serious eye damage H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 5-Bromocytosine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 2240-25-7

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