 Home > Encyclopedia > 5-Bromocytosine

5-Bromocytosine

5-Bromocytosine structure

CAS No:
2240-25-7
Formula:
C4H4BrN3O
Chemical Name:
5-Bromocytosine
Synonyms:
2(1H)-Pyrimidinone,6-amino-5-bromo-;Cytosine,5-bromo-;2(1H)-Pyrimidinone,4-amino-5-bromo-;6-Amino-5-bromo-2(1H)-pyrimidinone;5-Bromocytosine;4-Amino-5-bromo-2-hydroxypyrimidine;31295-39-3
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

Description

LIGHT YELLOW AMORPHOUS POWDER

5-Bromocytosine Basic Attributes

Molecular Weight：

190

Exact Mass：

190.00

EC Number：

218-806-8

UNII：

2737MSZ714

DSSTox ID：

DTXSID60176932

HScode：

2933599090

Characteristics

PSA：

67.5

XLogP3：

-0.3

Appearance：

White to yellow Solid

Density：

1.3±0.1 g/cm3

Melting Point：

245-255 °C (decomp)

Flash Point：

171.2±27.9 °C

Refractive Index：

1.583

Water Solubility：

Soluble in formic acid (50 mg/ml).

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-37/38-41-43-48-20/21/22

safety instructions：

24/25-22-36/37/39-26-45-7/8

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H317-H318-H335

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-bromocytosine

5-Bromocytosine Use and Manufacturing

The cytosine (55.6g, 0.5mol), N-bromosuccinimide (106.8g, 0 . 6mol) and DMF150mL in added in the reaction bottle, cooling to 15 °C ultrasonic reaction 1h, TLC raw material the reaction is complete, filtering, the filter cake is washed with water (20 ml × 2) washing, drying to obtain 5-bromocytosine (90.9g, 95.6percent).The cytosine (55.6g, 0.5mol), N-bromosuccinimide (106.8g, 0 . 6mol) and DMF150mL in added in the reaction bottle, cooling to 15 °C ultrasonic reaction 1h, TLC raw material the reaction is complete, filtering, the filter cake is washed with water (20 ml × 2) washing, drying to obtain 5-bromocytosine (90.9g, 95.6percent). (95g, 0.5 mol), acetic anhydride (306.3g, 3mol) added to the reaction flask, the reaction was warmed to 70 °C 4h, the solvent was distilled off under reduced pressure, was added 200mL of methanol was heated to reflux for 30min, cooled to room temperature, filtered, the filter cake was washed with 30mL of methanol, and drying to give N-acetyl-The remainder of the transformations are carried out substantially as described to produce first the corresponding 1-(3, 5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrimidine derivative and thereafter the 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrimidine derivative....5-fluorouracil, 6-azathymine, A mixture of compound

Computed Properties

Molecular Weight:190.00
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:188.95377
Monoisotopic Mass:188.95377
Topological Polar Surface Area:67.5
Heavy Atom Count:9
Complexity:208
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Sodium hydroxide

Recommended Suppliers of 5-Bromocytosine

Greenbo Biochem Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED Intermediates

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 99% Powder Professional Producer Greenbo

CAS No.: 2240-25-7

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Qingdao Orient Chemical Co.,LTD Contact Supplier

CN
1 YR

Business licensed

Trader Supplier of pharmaceutical intermediates,peptides,electronic chemicals

6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 2240-25-7

CAS No.: 2240-25-7

Grade: Industrial Grade

Content: 99%

Inquiry