Factory Supply Melanotan II Melanotan2 Powder 10mg Mt2 Tanning Peptide Melanotan 2 Fast Shipping to Norway Sweden UK Australia

1.  Description

     Chemical Properties: Melanotan 2 is a linear tetrapeptide compound with core functional groups comprising peptide bonds, carboxyl groups, and amino groups. It exhibits stable chemical properties and is resistant to hydrolysis in neutral to weakly acidic environments (pH 5.0-7.0), thereby avoiding the susceptibility to peptidase degradation characteristic of longer-chain peptides. Maintains structural integrity even after brief exposure to temperatures ≤100°C. Exhibits excellent compatibility with most bioactive ingredients such as vitamin C, ceramides, and hyaluronic acid, without generating allergenic byproducts.

     Physical Properties: Melanotan 2 appears as a white to off-white crystalline powder at room temperature, odorless and tasteless. It exhibits excellent water solubility (solubility ≥50 mg/mL), dissolving rapidly in aqueous systems like pure water and physiological saline. It is also soluble in polar organic solvents such as methanol and ethanol, but insoluble in non-polar solvents like diethyl ether and petroleum ether. Store at 2-8°C in a dry, sealed container protected from light. Both research-grade and application-grade products exhibit ≥98% purity (HPLC-detected) with single impurity ≤1.0%.

     Source and Preparation: Melanotan 2 has no natural occurrence and is precisely synthesized via solid-phase synthesis. Using high-purity L-type amino acids as starting materials, the target peptide chain is constructed through multiple reactions including condensation, deprotection, and column chromatography purification. The final high-purity product is obtained via recrystallization. The synthesis process strictly controls reaction temperature (25-30°C) and feed ratios to ensure structural integrity of the peptide chain and telomerase activation activity.

2.  Application

      Biomedical Research Field: Melanotan 2 serves as a core tool reagent for studying aging mechanisms, applied in research on telomerase activity regulation, cellular senescence signaling pathways (such as the p53/p21 pathway), neurodegenerative diseases (Alzheimer's disease, Parkinson's disease), and cardiovascular aging. Through cellular models like fibroblasts and neurons, as well as animal models including aged mice and premature aging mouse models, its effects on telomere length, aging biomarkers (β-galactosidase), and tissue function are analyzed, providing experimental evidence for anti-aging drug development.

     Premium Dietary Supplement Sector: Melanotan 2 serves as an anti-aging functional ingredient for developing dietary supplements like capsules and freeze-dried powders. It targets consumers focused on aging management (e.g., individuals over 40), immune enhancement (post-surgery/frail individuals), and physical function maintenance (high-stress professionals). Its small-molecule structure enables direct intestinal absorption without digestive breakdown, making it suitable for long-term anti-aging wellness and post-late-night recovery scenarios. Complies with EU and US dietary supplement regulatory standards.

     Premium Anti-Aging Skincare Sector: Leveraging cellular repair and anti-aging activity, Melanotan 2 is incorporated into serums, anti-aging creams, freeze-dried powders, and other high-end skincare products. Penetrates the skin's stratum corneum (transdermal absorption rate ≥35%), targeting dermal fibroblasts. Suitable for early signs of aging (ages 25-35) and mature skin (35+), it is gentle and non-irritating. Can be synergistically combined with anti-aging ingredients like peptides and boswellia for enhanced efficacy.

3. Main Efficacy

       Telomere Protection and Cellular Aging Delay Mechanism: Melanotan 2's core mechanism involves specifically activating the expression of telomerase reverse transcriptase (TERT), thereby extending and maintaining the length of telomeres at the ends of chromosomes. Telomeres serve as the “biological clock” of cellular aging, and their shortening is a key indicator of cells entering the senescence phase. Epitalon prolongs the division cycle of human fibroblasts by 2-3 times through inhibiting telomere attrition and promoting telomere repair, thereby delaying cellular aging and maintaining normal tissue and organ function.

     Antioxidant and Cellular Protection Effects: Melanotan 2 efficiently scavenges reactive oxygen species (ROS), hydroxyl radicals, and other oxidative agents within the body, reducing oxidative stress damage to cell membranes, DNA, and telomeres. Simultaneously, it upregulates the expression of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), enhancing the body's intrinsic antioxidant defense system and reducing oxidative damage to neurons and cardiomyocytes.

     Immune Modulation and Functional Enhancement: Melanotan 2 regulates the activity of immune cells such as lymphocytes and macrophages, promotes the secretion of immune factors like IL-2 and IFN-γ, and enhances the body's immune response capabilities against infection and injury. Simultaneously, it improves mitochondrial energy metabolism, increases ATP production efficiency, alleviates physical and mental fatigue, and offers potential protective effects on the nervous and cardiovascular systems. This can enhance cognitive function and motor abilities in the elderly.

      Skin Anti-Aging and Repair Effects: Melanotan 2 acts on skin fibroblasts to promote synthesis of Type III collagen (infantile core collagen) and elastin, increasing dermal thickness and significantly improving skin laxity and static fine lines. It simultaneously repairs damaged skin barriers, reduces transepidermal water loss (TEWL), and brightens skin tone uniformity, achieving dual effects of “deep anti-aging + barrier repair.”