FMOC-D-GLU-OTBU Dideu

Product Name: Fmoc-D-Ser(tBu)-OH
CAS No.: 128107-47-1
Molecular Formula: C₂₂H₂₅NO₅
Molecular Weight: 383.44 g/mol
Purity: 95%–99% (HPLC), customizable
Appearance: White to off-white crystalline powder

Product Overview

Fmoc-D-Ser(tBu)-OH is a specialized protected D-serine derivative featuring Fmoc (9-fluorenylmethoxycarbonyl) protection at the N-terminus and tert-butyl protection on the hydroxyl side chain. This dual-protection strategy provides exceptional stability during peptide synthesis while maintaining excellent solubility in organic solvents commonly used in solid-phase peptide synthesis (SPPS). 1 The compound serves as an essential chiral building block for incorporating D-serine residues into peptide sequences with precise stereochemical control, making it indispensable for advanced peptide research and pharmaceutical development.

Main Applications

Peptide Synthesis & Drug Discovery
Ideal for synthesizing D-amino acid containing peptides, including antimicrobial peptides, peptide hormones, and therapeutic candidates where D-configuration enhances metabolic stability and bioavailability. Particularly valuable in structure-activity relationship (SAR) studies for optimizing peptide drug candidates.

Chiral Catalyst Development
Serves as a precursor for asymmetric synthesis catalysts and chiral auxiliaries in organic chemistry, enabling the production of enantiomerically pure pharmaceutical intermediates and fine chemicals.

Biopharmaceutical Research
Extensively used in the development of peptide-based vaccines, diagnostic reagents, and targeted drug delivery systems where D-serine incorporation improves resistance to proteolytic degradation and extends half-life in biological systems. 3

Advanced Materials Science
Applied in the synthesis of self-assembling peptide nanomaterials, biomimetic polymers, and functional biomaterials for tissue engineering and regenerative medicine applications.

Custom Synthesis & CRO Services
A fundamental building block for contract research organizations (CROs) and pharmaceutical manufacturers engaged in custom peptide synthesis, GMP production, and large-scale API manufacturing.

Product Features

Premium Quality: ≥99.5% chiral purity (HPLC analysis) ensuring consistent performance in critical applications 3
Optimal Reactivity: Fmoc and tert-butyl protecting groups provide perfect compatibility with standard Fmoc-SPPS protocols and orthogonal deprotection strategies
Enhanced Stability: Low moisture content and exceptional shelf-life stability under proper storage conditions
Versatile Solubility: Soluble in DMF, DCM, acetonitrile, and other common peptide synthesis solvents
Batch-to-Batch Consistency: Rigorous quality control with comprehensive analytical documentation (HPLC, MS, NMR, chiral HPLC)
Scalable Production: Available from milligram to multi-kilogram quantities with consistent quality parameters
Packaging & Storage

Packaging Options: 1 g, 5 g, 10 g, 25 g, 100 g, 500 g, 1 kg, or customized bulk packaging with double-sealed containers under inert atmosphere
Storage Conditions: Store at -20°C in airtight containers, protected from light and moisture. Desiccant recommended for long-term storage.
Shelf Life: 24-36 months when stored under recommended conditions
Transport: Ambient temperature shipment acceptable for short durations; expedited shipping recommended for temperature-sensitive applications

Why Choose Us

Direct Manufacturer: Vertical integration from raw materials to finished products ensures competitive pricing and supply chain security
Comprehensive Documentation: Full analytical package including COA, HPLC chromatograms, MS/NMR spectra, chiral HPLC data, and safety documentation (SDS)
GMP Compliance: Production facilities certified for pharmaceutical-grade manufacturing with full traceability and documentation
Technical Expertise: Dedicated peptide chemistry specialists providing application support, synthesis optimization, and custom manufacturing solutions
Global Logistics: Efficient worldwide shipping with customs clearance assistance and regulatory compliance support for international markets
Flexible MOQ: Low minimum order quantities for research-scale needs with scalable options for commercial production requirements
Note: All specifications subject to change without notice. Contact us for customized purity requirements, special packaging, or bulk pricing inquiries.