4-Bromo-2-fluoroaniline 367-24-8 C6H5BrFN

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Product Name: 4-Bromo-2-fluoroaniline Synonyms: Benzenamine, 4-bromo-2-fluoro-;AKOS BBS-00003609;4-Bromo-2-fL;2-Fluoro-4-Bromoaniline;4-Bromo-2-fluoroaniline 99%;4-Bromo-2-fluoroaniline99%;Bromofluoroaniline4;-BROMO-2-FLUOROANILINE, 98% CAS: 367-24-8 MF: C6H5BrFN MW: 190.01 EINECS: 206-685-4 Product Categories: Trifluoromethoxybenzene Series;Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds;Amines;C2 to C6;Fluorobenzene;Fluoro-Aromatics;PHARMACEUTICAL INTERMEDIATES;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Benzenes;Nitrogen Compounds;amine| alkyl Fluorine| alkyl bromide Mol File: 367-24-8.mol 4-Bromo-2-fluoroaniline Chemical Properties Melting point  40-42 °C Boiling point  103-108 °C (13 mmHg) density  1.6196 (rough estimate) refractive index  1.4710 (estimate) Fp  220 °F storage temp.  Keep in dark place,Inert atmosphere,Room temperature pka 2.50±0.10(Predicted) form  Crystalline Mass, Powder, Crystals and/or Chunks color  Beige to light brown to brown-gray or gray BRN  2081089 Stability: Stable. Incompatible with acid chlorides, acid anhydrides, strong acids, strong oxidizing agents. InChI InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2 InChIKey GZRMNMGWNKSANY-UHFFFAOYSA-N SMILES C1(N)=CC=C(Br)C=C1F CAS DataBase Reference 367-24-8(CAS DataBase Reference) NIST Chemistry Reference 4-Bromo-2-fluoroaniline(367-24-8) Safety Information Hazard Codes  Xi,T,Xn Risk Statements  36/37/38-20/21/22 Safety Statements  26-37/39-36/37/39-36 RIDADR  UN2811 WGK Germany  3 Hazard Note  Toxic HazardClass  6.1 PackingGroup  III HS Code  29214200 MSDS Information 4-Bromo-2-fluoroaniline Usage And Synthesis Chemical Properties solid Uses 4-Bromo-2-fluoroaniline can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes. Uses 4-Bromo-2-fluoroaniline was used in synthesis of 4-amino-3-fluorophenyl boronic acid. It was also used in chemical modification and synthesis of boronic acid derivatives for ultraviolet-visible titration. Synthesis To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 ??C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline. References [1] Journal of Organic Chemistry, 2005, vol. 70, # 11, p. 4267 - 4271 [2] Beilstein Journal of Organic Chemistry, 2012, vol. 8, p. 744 - 748 [3] Tetrahedron Letters, 2015, vol. 56, # 41, p. 5646 - 5650 [4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869 [5] Patent: CN106905168, 2017, A. Location in patent: Paragraph 0026-0029

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



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