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Scopolamine 51-34-3

TDS 85 Inquiries

Unit Price:

$9-11/G FOB

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CAS No.:

51-34-3

Grade:

Pharmaceutical Grade

Content:

99.99%

Port:

shanghai

Brand:

Orient

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-10-11

Company Type:
Trader
Location:
China
Qualification:
Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Scopolamine

    Properties

    Melting point: 59 ºC Specific rotation: [α]D20 -28° (c = 2.7) Boiling point: 444.28°C (rough estimate) Density: 1.31 Refractive index: 1.5022 (estimate) Flash point: 232.2℃ Storage condition: -20°C Solubility: Soluble in water and 96% ethanol. pKa: 7.55-7.81(at 25℃) Form: Solid below 55°C, liquid above 55°C Color: White to off-white Water solubility: 95g/L(15 ºC) LogP: 0.980 NIST: Scopolamine(51-34-3) EPA: Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (.alpha.S)- (51-34-3)

    Description & Synthesis Information

    Scopolamine is a tropane alkaloid naturally found in Solanaceae plants such as Scopolia japonica, Datura metel and Datura stramonium. It is a white crystalline powder. It is slightly soluble in water, freely soluble in ethanol, very soluble in chloroform and dichloromethane, soluble in non-volatile oils and benzene. It contains chiral carbon atoms, and the levorotatory form has strong activity.

    This compound was first isolated from Scopolia plants by E. Schmidt in 1892. In recent years, research on its biosynthesis has made progress. Research teams have analyzed the biosynthetic pathway of scopolamine and related enzyme catalytic mechanisms. Other studies have applied synthetic biology to produce scopolamine and hyoscyamine in yeast for development of related compounds and biosensors.

    Applications

    Scopolamine is an alkaloid extracted from belladonna plants. It can block parasympathetic nerves and act as a central nervous system depressant. Its effect is similar to atropine but stronger and shorter in duration. Its hydrobromide salt is commonly used in commercial formulations. It can be applied for motion sickness management and relieving stiffness and tremor.

    Chemical Safety Information

    Flammability: Combustible; decomposes to release toxic nitrogen oxide fumes under fire conditions. Storage & transport: Store in low-temperature, ventilated and dry warehouse. Fire extinguishing media: Water, carbon dioxide, dry powder, sand.


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    ECHEMI Editorial Reference
    Scopolamine is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM.
    LSM-1330 is a 3-hydroxy carboxylic acid.|Scopolamine as a natural plant alkaloid that has potent anticholinergic effects and is used to treat mild to moderate nausea, motion sickness and allergic rhinitis. Scopolamine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.|An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic.
    White or almost white, crystalline powder or colourless crystals.
    Scopolamine is the main active ingredient of Scopolia japonica, Datura metel L., and other Solanaceae plants. As early as 1892, the chemist E.Schmidt first isolated it from the Scopolia japonica, so named it as scopolamine. Due to its obvious deficiencies in solubility and usage, the researchers modified its structure as scopolamine butylbromide, which was synthesized and used scopolamine and bromo-n-butane with heating refluxing method. Preparation method of scopolamine butylbromide is simple, and it’s easy to be synthesized. There are about 170 domestic enterprises producing its raw materials currently.European Pharmacopoeia (9th ed.), United States Pharmacopeia (36), and the Japanese Pharmacopoeia (16th ed.) contained bromine scopolamine; British Pharmacopoeia (2015) contained the raw materials and preparations of scopolamine butylbromide, including tablets and injections. Pharmacopoeia of the People’s Republic of China (2015) contained its raw materials, injection, and capsules.
    ChEBI: A tropane alkaloid that is the (S)-tropic acid ester of 6beta,7beta-epoxy-1alphaH,5alphaH-tropan-3alpha-ol.

    Certificates

    Basic Info
    Product Name:

    Scopolamine

    Other Name:

    6,7-Epoxytropine tropate;Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, (.alpha.S)-;1aH,5aH-Tropan-3a-ol, 6b,7b-epoxy-, (-)-tropate (ester) (8CI);3-Oxa-9-azatricyclo[3.3.1.02,4]nonane, benzeneacetic acid deriv.;6b,7b-Epoxy-3a-tropanyl S-(-)-tropate;9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-tropate;Atrochin;Atroquin

    CAS No.:

    51-34-3

    Molecular Formula:

    C17H21NO4

    InChIKeys:

    InChIKey=STECJAGHUSJQJN-FWXGHANASA-N

    Molecular Weight:

    303.35

    Exact Mass:

    303.35

    EC Number:

    200-090-3

    DSSTox ID:

    DTXSID6023573

    Color/Form:

    White to off-white

    ATC Code:

    A - Alimentary tract and metabolism|N - Nervous system|S - Sensory organs

    HScode:

    29399990

    Characteristics
    PSA:

    62.30000

    Physical Properties:

    Appearance: a kind of viscous liquid, brown color. Solubility: soluble in ethanol, ethyl ether, chloroform, acetone, and water, very soluble in hot water, slightly soluble in benzene and petroleum ether, and also soluble in cold water. It can generate various crystals with multiple inorganic or organic acids. Melting point: 59±1.0°C

    XLogP3:

    0.76

    Appearance:

    White crystalline powder

    Density:

    1.31

    Melting Point:

    59 ºC

    Boiling Point:

    444.28°C (rough estimate)

    Flash Point:

    232.2℃

    Refractive Index:

    1.5022 (estimate)

    Water Solubility:

    95g/L(15 ºC)

    Storage Conditions:

    -20°C

    Vapor Pressure:

    7.18X10-9 mm Hg at 25 °C (est)

    Toxicity:

    A belladonna plant alkaloid that exerts its pharmacodynamic effects by blocking muscarinic acetylcholine receptor sites. The s.c. LD50 of scopolamine hydrobromide in mice is 3.8 g/kg. Scopolamine crosses the blood brain barrier, and its antimuscarinic effects include, in therapeutic doses, drowsiness, euphoria, amnesia, fatigue, loss of REM sleep and, at higher doses, restlessness or even delirium. Scopolamine can be used to treat motion sickness and parkinsonian tremor. The effects of scopolamine may be greater in the CNS than atropine, and it may be a better antidote for organophosphate intoxication.

    Flammability characteristics:

    Combustible; Fire breaks down toxic nitrogen oxide fumes

    Specific rotation:

    D20 -28° (c = 2.7)

    PKA:

    7.55-7.81(at 25℃)

    Henrys Law Constant:

    Henry's Law constant = 3.36X10-16 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa = 7.75

    Experimental Properties:

    Crystals. Freely soluble in water, dilute alcohol; slightly soluble in absolute alcohol /Methyl nitrate/|Dihydrate: chisel-shaped prisms from ethanol+water, mp 38-40 °C. Monohydrate: efflorescent crystals, mp 55-57 °C. Anhydrous: long prisms, mp 82-82 °C. Very slightly soluble in water; soluble in alcohol, chlorform, ether, oils /DL-form/|ODORLESS /SCOPOLAMINE HYDROBROMIDE USP/|COLORLESS OR WHITE CRYSTALS OR WHITE GRANULAR POWDER /SCOPOLAMINE HYDROBROMIDE NF/|Hydroxyl radical reaction rate constant = 5.97X10-11 cy cm/molec-sec at 25 °C (est)

    Critical Temperature & Pressure:

    -20°C

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 2, Oral

    Acute toxicity - Category 1, Dermal

    Acute toxicity - Category 2, Inhalation

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H300 Fatal if swallowed

    H310 Fatal in contact with skin

    H330 Fatal if inhaled

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P262 Do not get in eyes, on skin, or on clothing.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    P284 [In case of inadequate ventilation] wear respiratory protection.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P316 Get emergency medical help immediately.

    P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P320 Specific treatment is urgent (see ... on this label).

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    pharmaceutical intermediates,peptides,electronic chemicals

    Location:

    Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

    Payment Terms:

    100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $10 million-$25 million

    Total Employees:

    51-100

    Year of Establishment:

    2024

    A reliable supplier is like insurance.

    We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals,food additives, and other fine chemical products.
    Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

    Website: orientchem.cc
    Email: scarlett@orientchem.cc
    WhatsApp: +86 17753254221

  • Inquiry History
    85 Inquiries
    Country Product Purchase Quantity Date Posted
    Bangladesh

    Scopolamine CAS 51-34-3 99%

    1 KG Oct 30, 2023
    United States

    Scopolamine 99.9% Powder 51-34-3 DW

    50 MT Oct 19, 2023
    Bangladesh

    Factory price CAS 51-34-3 Scopolamine powder

    100 G Nov 6, 2023
    Bangladesh

    Safe Delivery Scopolamine 99% Solid CAS 51-34-3

    10 G Nov 4, 2023
    Bangladesh

    Safe Delivery Scopolamine 99% Solid CAS 51-34-3

    10 G Oct 21, 2023
    Bangladesh

    Safe Delivery Scopolamine 99% Solid CAS 51-34-3

    100 G Oct 12, 2023
    Bangladesh

    Safe Delivery Scopolamine 99% Solid CAS 51-34-3

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    1 KG Oct 17, 2023
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    01850035067 MT Oct 14, 2023
    United States

    Scopolamine hot sale CAS 51-34-3 wholesale Scopolamine powder

    5 G Sep 22, 2023
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    Scopolamine hot sale CAS 51-34-3 wholesale Scopolamine powder

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    1 G Nov 6, 2023
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    Scopolamine 99% white powder 51-34-3 99% White A Scopolamine 99%

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    France

    China Factory Sell 99% Scopolamine powder/ pure Scopolamine / API Scopolamine 51-34-3

    10 G Oct 24, 2023
    Bangladesh

    Scopolamine

    100 KG Apr 22, 2025
    United States

    scopolamine

    1 KG Jul 31, 2026
    Bangladesh

    scopolamine

    100 G Jul 22, 2026
    Austria

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    1 MT Jul 6, 2026
    Canada

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    1 G Apr 9, 2026
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