PNC-27 Anti-cancer peptide, used for cancer treatment, factory supply, with favorable price.

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PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.

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1. Own your own chemical plant

2. Rich professional production experience

3. Sample free and in stock, delivery

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Our advantage

1. Own your own chemical plant

2. Rich professional production experience

3. Sample free and in stock, delivery

4. Price, quality and service, we care about all your concerns

5. Timely reply Keep in touch to save your time

6. Easy customs clearance, we have all these controlsAll very good

7. Dedicated researchers customize it for you.

Peptide Storage Guidelines: General Tips
When storing peptides, remember to:
• Store peptide in a cold, dry, dark place
• Avoid repeated freezing and thawing of peptide
• Avoid overexposure to the air
• Avoid light exposure
• Avoid storing peptides in solution long term
• Aliquot peptide according to experimental requirements