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D-Pantethine CAS:16816-67-4

Name: D-Pantethine CAS:16816-67-4
Brand: Orient
SKU: pr2512241511
Price: 4 USD
Availability: InStock

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CAS No.:

16816-67-4

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

1KG, 5KG, 25KG

Price valid (until):

2026-01-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	D-Pantethine
Synonyms:	bis(pantothenamidoethyl)disulfide;butyramide,n,n’-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,;d-(+)-3-dimethyl;d-bis(n-pantothenyl-beta-aminoethyl)disulfide;d-pantethineanhydrous;lbfdisulfide;PANTETHIN;Butanamide, N,N-dithiobis2,1-ethanediylimino(3-oxo-3,1-propanediyl)bis2,4-dihydroxy-3,3-dimethyl-, (2R,2R)-
CAS:	16816-67-4
MF:	C22H42N4O8S2
MW:	554.72
EINECS:	240-842-8
Product Categories:	Inhibitors
Mol File:	16816-67-4.mol

D-Pantethine Chemical Properties

alpha	D27 +13.5° (c = 3.75 in water)
Boiling point	987.2±65.0 °C(Predicted)
density	1.1949 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	Methanol (Slightly), Water (Slightly)
pka	12.71±0.20(Predicted)
form	syrup
color	Crystals from MeOH/Me2CO
biological source	synthetic (organic)
Stability:	Hygroscopic
Cosmetics Ingredients Functions	HAIR CONDITIONING SKIN CONDITIONING - EMOLLIENT
InChIKey	DJWYOLJPSHDSAL-ROUUACIJSA-N
SMILES	S(CCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

Safety Information

WGK Germany	3
RTECS	ES4392700
Toxicity	LD50 oral in rat: > 10gm/kg

MSDS Information

D-Pantethine Usage And Synthesis

Description	D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. It is known that the sulfhydryl group is the metabolically active part of the molecule. Coenzyme A is an essential cofactor in over 70 biological pathways, such as fatty acid oxidation, carbohydrate metabolism, and amino acid catabolism. Studies conducted in vitro suggest that D-Pantethine inhibits the activity of aldehyde dehydrogenase; however, related metabolites of the compound, such as Taurine (sc-202354), D-pantetheine, Coenzyme A, and D-pantothenate activate this enzyme.
Chemical Properties	Colorless to pale yellow, clear, viscous liquid
Originator	Atarone,Vinas
Uses	antilipemic
Definition	ChEBI: An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.
Manufacturing Process	To 11 g of hydrazine hydrate (85%) cooled in an ice bath are added 11.5 g of methyl d-pantothenate and the cold mixture is stirred vigorously. After the reaction takes place and the mixture is warmed to 30°C, it is allowed to stand at room temperature for two days, and then evaporated to dryness in vacuo at 50°C. The residue (14.7 g) of pantothenyl hydrazide is a clear glassy oil. To 7.3 g of crude d-pantothenyl hydrazide dissolved in 21 ml of water and stirred in a beaker cooled on an ice bath is added sufficient. 6 N hydrochloric acid to shift the pH to 4. Then a solution of 1.7 g of sodium nitrite in 5 ml of water is added dropwise over a period of one hour, keeping the pH at 4 by additions of 6 N hydrochloric acid. After stirring for one-half hour, 2.8 g of bis(β-aminoethyl)disulfide dihydrochloride are added. The pH is then adjusted to 8.5 with 50% aqueous sodium hydroxide solution and the solution allowed to stir for one and one-half hours. It is then acidified to pH 7.5 and concentrated in vacuo to clear colorless viscous oil. The pure product can be isolated from this oil by the next method. The crude bis(Npantothenylamidoethyl)disulfide so obtained is purified by dissolving the crude reaction product in 45 ml of anhydrous n-butanol and pouring the resulting solution through a chromatograph column containing 272 g of activated carbon. The column is washed with n-butanol and fractions are collected from time to time and the fractions containing solids assaying about 25 to 40% pure bis(N-pantothenylamidoethyl)disulfide against Lactobacillus: helveticus 80 poured onto a chromatograph column containing 136 g of an alkaline earth aluminum silicate known commercially as Super -filtrol. The column is washed thoroughly with anhydrous n-butanol and the washings and main solution discarded. N-Butanol saturated with water is poured through the column to elute the bis(N-pantothenylamidoethyl)disulfide and the resulting solution evaporated to dryness in vacuum at low temperature to obtain the desired product in pure form. Instead of pouring the anhydrous n-butanol solution onto the alkaline earth aluminum silicate chromatograph column, one can simply repeat the treatment with a carbon chromatograph column to obtain the pure product. In some instances, the first carbon treatment produces fractions containing pure bis(N-pantothenylamidoethyl)disulfide and in those cases it is, of course, not necessary to treat the fraction with alkaline earth aluminum silicate nor again with activated carbon.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Pantethine

Other Name:

Butanamide,N,N′-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-,(2R,2′R)-;Butyramide,N,N′-[dithiobis(ethyleneiminocarbonylethylene)]bis[2,4-dihydroxy-3,3-dimethyl-,D-(+)-;Butanamide,N,N′-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-,[R-(R*,R*)]-;(2R,2′R)-N,N′-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide];D-Pantethine;D-Bis-pantothenyl-β-aminoethyl disulfide;Pantethine;LBF disulfide;Bis(pantothenamidoethyl) disulfide;Pantosin;Pantomin;Pantetina;Bis(N-pantothenylamidoethyl) disulfide;Panthecin;Lipodel;303-05-9

CAS No.:

16816-67-4

Molecular Formula:

C22H42N4O8S2

InChIKeys:

InChIKey=DJWYOLJPSHDSAL-ROUUACIJSA-N

Molecular Weight:

554.73

Exact Mass:

554.72

EC Number:

240-842-8

NSC Number:

759269

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

248

XLogP3:

-2.2

Appearance:

syrup

Density:

1.1949 (rough estimate)

Boiling Point:

987.2±65.0 °C(Predicted)

Flash Point:

550.8ºC

Refractive Index:

1.6000 (estimate)

Storage Conditions:

2-8°C

Vapor Pressure:

0mmHg at 25°C

Toxicity:

LD50 oral in rat: > 10gm/kg

Specific rotation:

D27 +13.5° (c = 3.75 in water)

See More Pantethine Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H400 Very toxic to aquatic life
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Pantethine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

9 Inquiries

Country	Product	Purchase Quantity	Date Posted
Australia	pharmaceutical Pantethine Powder CAS 16816-67-4	1 KG	Oct 23, 2024
South Korea	Pantethine	1 KG	Jul 9, 2025
Turkey	Pantethine	1 MT	Mar 27, 2025
South Korea	China Most Professional Manufacturer Supply High Qulity Pantethine	10 KG	Dec 19, 2024
Poland	D-Pantethine	17 KG	Sep 11, 2024
United Kingdom	Pantethine	120 KG	Jun 19, 2024
Austria	Pantethine	1 KG	Jun 17, 2025
Australia	D-Pantethine,	1 KG	Aug 10, 2024
Croatia	Pantethine	1 KG	Feb 5, 2024

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