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D-Pantethine

D-Pantethine structure

CAS No:
16816-67-4
Formula:
C22H42N4O8S2
Chemical Name:
D-Pantethine
Synonyms:
bis(pantothenamidoethyl)disulfide;butyramide,n,n’-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,;d-(+)-3-dimethyl;d-bis(n-pantothenyl-beta-aminoethyl)disulfide;d-pantethineanhydrous;lbfdisulfide;PANTETHIN;Butanamide, N,N-dithiobis2,1-ethanediylimino(3-oxo-3,1-propanediyl)bis2,4-dihydroxy-3,3-dimethyl-, (2R,2R)-
Categories:
Cosmetic Ingredient > Hair Conditioning

Description

Colorless to pale yellow, clear, viscous liquidChEBI: An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.

Bis(N-pantothenylamidoethyl) disulfide is an organonitrogen compound and an organooxygen compound. It derives from a beta-amino acid.

D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. It is known that the sulfhydryl group is the metabolically active part of the molecule. Coenzyme A is an essential cofactor in over 70 biological pathways, such as fatty acid oxidation, carbohydrate metabolism, and amino acid catabolism. Studies conducted in vitro suggest that D-Pantethine inhibits the activity of aldehyde dehydrogenase; however, related metabolites of the compound, such as Taurine (sc-202354), D-pantetheine, Coenzyme A, and D-pantothenate activate this enzyme.

Colorless to pale yellow, clear, viscous liquid

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

D-Pantethine Basic Attributes

Molecular Weight：

554.72

Exact Mass：

554.72

EC Number：

240-842-8

NSC Number：

759269

Color/Form：

Crystals from MeOH/Me2CO

Characteristics

PSA：

248

XLogP3：

-2.2

Appearance：

syrup

Density：

1.1949 (rough estimate)

Boiling Point：

987.2±65.0 °C(Predicted)

Flash Point：

550.8ºC

Refractive Index：

1.6000 (estimate)

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

LD50 oral in rat: > 10gm/kg

Specific rotation：

D27 +13.5° (c = 3.75 in water)

PKA：

12.71±0.20(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

ES4392700

Precautionary statement(s)：

P273, P391, P501

Hazard Statements：

H400

D-Pantethine Use and Manufacturing

antilipemic

Computed Properties

Molecular Weight:554.7
XLogP3:-2.2
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:19
Exact Mass:554.24440666
Monoisotopic Mass:554.24440666
Topological Polar Surface Area:248
Heavy Atom Count:36
Complexity:652
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It improves fat metabolism, reduces triglycerides, accelerates the β-oxidation process of fatty acids in the liver and arterial walls, and inhibits fat peroxidation products. It also increases the activity of fat metabolism enzymes and cholesterol esterase, and increases the content of high-density lipid cholesterol in serum.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pantethine Capsules
Ingredients	Pantethine.
Indication	Not yet clear.
Specifications	0.1g12s2 plates

Pantethine Capsules
Ingredients	Pantethine. Chemical name: N,N,-[disulfide bis[2,1-diethylimino (3-oxo-3,1-propanediyl)]] bis[2,4-dihydroxy-3,3-dimethylbutyramide] Molecular weight: C22H42N4O8S2
Specifications	0.2g

Pantethine Tablets
Ingredients	The active ingredient of this product is pantethine. Chemical name: N,N,-[disulfide bis[2,1-diethylimino (3-oxo-3,1-propanediyl)]] bis[2,4-dihydroxy-3,3-dimethylbutyramide] Chemical structure: Molecular formula: C22H42N4O8S2 Molecular weight: 554.73
Indication	This experiment has not been conducted and there are no reliable references.

See More Related Drugs

Registered Holders

Yifan Pharmaceutical Co., Ltd.

China
Active
Hefei Cosource Heyuan Pharmaceutical Co., Ltd.

China
Active
SIGMA F AND D DIV LTD

United States
Inactive

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