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Retatrutide Retatrutide safe delivery strong Lyophilized powder Vial

Name: Retatrutide Retatrutide safe delivery strong Lyophilized powder Vial
Brand: Guangsheng
SKU: pr2601141066
Price: 60 USD
Availability: InStock

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CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Guangzhou

Brand:

Guangsheng

Packaging:

5-60mg*10vials

Price valid (until):

2026-02-14

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Guangsheng Technology co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

beaty prodt

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Name: Lynn
Wechat： 15914422644

Tel：+86 15914422644

Whatsapp: + 852 6252 8290

Email： guangsheng 5 @zgguangsheng.com

Product Detail

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1. Core Molecular & Physical Traits

Structure: 39-amino acid synthetic peptide with a lipid diacid moiety for extended half-life.
Formula/MW: C₂₂₃H₃₄₃F₃N₄₆O₇₀; 4845.44 Da.
Formulation: Subcutaneous injection (lyophilized powder), once-weekly dosing.
Pharmacokinetics: Half-life ~6 days; dose-proportional absorptionPubMed.
Purity: ≥99% (HPLC), ensuring high bioactivity.

2. Mechanism of Action (Triple Receptor Synergy)

Receptor	Key Actions
GLP-1R	Glucose-dependent insulin secretion; glucagon suppression; delayed gastric emptying; enhanced satiety
GIPR	Improved insulin sensitivity; lipid metabolism regulation; synergizes with GLP-1R for weight loss
GCGR	Boosts energy expenditure; reduces hepatic fat deposition; enhances lipolysis

Collectively, it curbs appetite, accelerates fat breakdown, improves glycemic control, and reduces liver fat.

3. Clinical Efficacy Data

Trial	Duration	Doses	Key Outcomes
Phase 2 (Obesity)	48 weeks	8/12 mg/week	Avg. weight loss: 24–28.7% (vs. ~15% for dual agonists)
Phase 3 (Triumph-4)	68 weeks	12 mg/week	Max. weight loss 28.7%; reduced knee pain by 75.8%
Type 2 Diabetes	24 weeks	4–12 mg/week	HbA1c ↓1.8–2.2%; fasting glucose ↓30–40 mg/dL
Hepatic Steatosis	24 weeks	8 mg/week	Liver fat content ↓40–50%

4. Safety & Tolerability

Common Side Effects: Mild–moderate, transient GI issues (nausea, diarrhea, vomiting).
Key Advantages: Low severe hypoglycemia risk (monotherapy); minimal impact on bone density/hormones.
Precautions: Avoid in medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or hypersensitivity.

5. Application Scenarios

Obesity: Long-term weight management (adjunct to lifestyle changes).
Type 2 Diabetes: Adjunct therapy for glycemic control and weight reduction.
Metabolic Comorbidities: Non-alcoholic fatty liver disease (NAFLD), knee osteoarthritis (weight-related).
Future Potential: NASH, cardiovascular risk reduction, and body composition improvement.

6. Development Status

As of early 2026, it is in late-stage Phase 3 trials (e.g., TRIUMPH program). Eli Lilly plans to file for FDA approval in 2026, with potential launch in 2027.

Index	Standard	Test Method
Appearance	White to off-white lyophilized powder	Visual Inspection
Molecular Formula	C₂₂₁H₃₄₂N₄₆O₆₈	Mass Spectrometry
Molecular Weight	4731.33	Calculated & Verified by MS
Solubility	Soluble in water, dilute acid	Shake Test (25℃)Sterility
Sterility	Meets pharmaceutical R&D standards	Membrane Filtration Method

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ECHEMI Editorial Reference

Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.

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Basic Info

Product Name:

Retatrutide

Other Name:

Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

CAS No.:

2381089-83-2

Molecular Formula:

C221H342N46O68

InChIKeys:

MLOLQJNKXBNWFW-SAGGEDDASA-N

Molecular Weight:

4731.33

EC Number:

200-001-8

Color/Form:

White lyophilized

Categories:

Other Chemical Drugs

Characteristics

Water Solubility:

Soluble in water (5mg/ml).

Storage Conditions:

-20°C

Critical Temperature & Pressure:

-20°C

Research

Class:

Triple agonist — GCGR, GIPR, GLP-1R

Status:

Investigational (Phase 3)

Mechanism:

Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

EC50 (Human GCGR):

5.79 nM

EC50 (Mouse GIPR):

0.191 nM

EC50 (Mouse GLP1R):

0.794 nM

EC50 (Mouse GCGR):

2.32 nM

EC50 (Human GLP1R):

0.775 nM

EC50 (Human GIPR):

0.0643 nM

Source:

Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

Clinical Development:

NCT04881760; NCT05882045; NCT06354660

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA

Disclaimer:

Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

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Seller Information

Business Type:
Trader

Main Products:
beaty prodt

Location:
Yongtai Jinli City Plaza, Baiyun District, Guangzhou City, Guangdong Province

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2023

Inquiry History

6934 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Retatrutide 2381089-83-2	3 MT	Mar 28, 2026
United Kingdom	Retatrutide - 2381089-83-2	1 G	Feb 10, 2026
United States	Retatrutide CAS 2381089-83-2 10mg vial	20 MT	Mar 7, 2026
United States	Factory Retatrutide API 99% Purity CAS 2381089-83-2	5 KG	Nov 10, 2025
United Kingdom	Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA	1 MT	Mar 22, 2026
United States	2381089-83-2	100 G	Jul 14, 2026
United States	2381089-83-2	100 G	Feb 24, 2026
United States	2381089-83-2	100 MT	Dec 9, 2023
United States	Retatrutide 2381089-83-2	200 MG	May 16, 2026
United Kingdom	2381089-83-2 retatrutide	300 MG	Feb 13, 2026
United States	Retatrutide 2381089-83-2 wholesale	500 MT	Nov 3, 2023
United States	Retatrutide CAS 2381089-83-2 99%	10 PCS	Feb 21, 2026
Poland	CAS 2381089-83-2 (Custom Peptide)	40 MT	Apr 10, 2026
Austria	Peptide Retatruide CAS 2381089-83-2	100 MT	Apr 4, 2026
Austria	Retatrutide CAS 2381089-83-2 10mg vial	20 PCS	Feb 10, 2026
United States	GLP-1 / GIP Retatrutide cas 2381089-83-2	1 MT	Oct 16, 2024
United States	Retatrutide 99% High Quality CAS 2381089-83-2	1 G	Jan 23, 2026
United States	Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2	10	Oct 21, 2023
Australia	GMP Grade 99% Retatrutide Lyophilized Powder CAS 2381089-83-2	10 G	Jun 12, 2026
Palestine	Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service	10 MG	Mar 16, 2026

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