High purity Cortagen

Name:  Lynn
Wechat：  15914422644

Tel：+86  15914422644

Whatsapp: +852 6252 8290

Email：    guangsheng 5   @zgguangsheng.com

1. Core Molecular & Physicochemical Specifications

2. Mechanism of Action

1. Epigenetic Regulation: Enters cell nuclei, binds to DNA, and adjusts the transcription of genes related to neuronal renewal, chromatin stability, and DNA repair, restoring a youthful gene expression profile in aging neural cells.
2. Neuroprotection: Reduces oxidative stress, balances pro - inflammatory and anti - inflammatory pathways in the central nervous system, and shields neurons from ischemic, traumatic, or age - related damage.
3. Neuroregeneration: Promotes neuronal repair, enhances synaptic plasticity, and accelerates the recovery of nerve function after injury or transection.
4. Immune - Neuro Modulation: Stimulates interleukin - 2 expression, regulates immune function, and reduces autoimmune reactions, maintaining the neuro - immune balance.

3. Biological Functions & Research Applications

3.1 Core Biological Effects

• Neuroregeneration: Accelerates neuronal repair and recovery of neural function post - injury, including spinal cord and brain ischemic damage.
• Cognitive Enhancement: Improves memory, concentration, and information processing by boosting synaptic plasticity.
• Neuroprotection: Guards against oxidative stress, inflammation, and age - related neurodegeneration, potentially delaying the progression of neurodegenerative diseases.
• Anti - Aging: Restores the youthful state of neural cell DNA, reduces cellular senescence, and supports nervous system longevity.
• Stress Adaptation: Enhances the nervous system's resilience to emotional and environmental stress, stabilizing mood.

3.2 Research Applications

4. Production & Quality Control

4.1 Manufacturing Process

1. Solid - Phase Peptide Synthesis (SPPS): Fmoc chemistry assembles the Ala - Glu - Asp - Pro sequence, purified by reversed - phase high - performance liquid chromatography (RP - HPLC) to reach ≥99% purity.
2. Lyophilization: Freeze - drying forms stable powder, extending shelf - life and facilitating cold - chain storage and transportation.

4.2 Quality Testing Standards

5. Administration, Safety & Handling

5.1 Administration Routes & Dosage

• Subcutaneous Injection: Common in animal research; 100 - 500 mcg/kg/day for 10 - 30 days to support neuroregeneration and neuroprotection.
• Intraperitoneal Injection: Used in acute neuroinjury models; 200 - 600 mcg/kg/day for 7 - 14 days to reduce ischemic damage.
• Oral Administration: Research - grade capsules; 10 - 20mg/day for 2 - 4 weeks for cognitive and anti - aging studies.

5.2 Safety Profile

• Low Toxicity: Transient mild injection - site reactions or mild gastrointestinal discomfort (rare, dose - dependent, and reversible).
• Non - Immunogenic: No allergic reactions reported; compatible with standard neuroscience research protocols.
• Contraindications: Hypersensitivity to Cortagen; pregnancy/lactation (limited data); caution in severe renal/hepatic dysfunction.

5.3 Handling Recommendations

• Storage: Store at - 20°C in a dry, dark environment; protect from light and moisture.
• Transport: Transport under cold - chain conditions (2 - 8°C) to ensure stability.
• Research - Only Use: High - purity powder is for R&D only; not for human clinical use without regulatory approval.
• Disposal: Dispose of in accordance with local chemical waste regulations to prevent environmental pollution.

6. Advantages of High - Purity Cortagen Powder

1. Epigenetic Targeting: High purity ensures precise modulation of neural gene expression, minimizing off - target effects and ensuring reliable experimental results.
2. Neuroregenerative Potential: Unique ability to promote neuronal repair, making it ideal for neuroinjury and neurodegeneration research.
3. Safety & Compatibility: Low toxicity allows long - term use in animal models and combination with other research interventions.
4. Stable Activity: Low impurity content maintains consistent biological activity during the research cycle.