Product Detail  

CAS Number: 1802220-02-5 Chemical Name: (S)-N-(5-((3,5-Difluorophenyl)amino)-1H-pyrazol-3-yl)-3-(hydroxymethyl)-1-methylpiperidine-4-carboxamide Molecular Formula: C₂₃H₂₂F₂N₆O₂ Molecular Weight: 436.46 g/mol Synonyms: Augtyro®, TPX-0005 Related Categories: Next-Generation ALK/ROS1/NTRK Inhibitor, Oral Selective Tyrosine Kinase Inhibitor (TKI), Multi-Targeted Fusion Kinase Inhibitor, ALK/ROS1/NTRK-Positive NSCLC & Solid Tumor Therapeutic Key Highlight: A potent, next-generation oral TKI with pan-inhibitory activity against ALK, ROS1 and NTRK fusion mutations, including a broad spectrum of acquired resistance mutations; features exceptional central nervous system (CNS) penetration, effective for brain metastases; indicated for ALK/ROS1-positive metastatic NSCLC and NTRK fusion-positive solid tumors, exerts anti-tumor effects by blocking aberrant fusion kinase signaling to inhibit tumor cell proliferation and survival.