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Reptectinib Crude

Name: Reptectinib Crude
Brand: Kindchem
SKU: pr2308311596
Price: 10 USD
Availability: InStock

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CAS No.:

1802220-02-5

Grade:

Industrial Grade

Content:

98%

Brand:

Kindchem

Packaging:

25kg/Drum

Price valid (until):

2024-07-06

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Kindchem Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

API OLED Organic intermediate,1-Cyclopentene-1-carbonitrile ,Cyclohexanol, 4-chloro- ,1,3-Cyclohexanedione,2,2-Dimethyl-1,3-cyclohexanedione,6-Bromo-1,2,3,4-tetrahydroquinoline

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Description

Product Name Ropotrectinib
Appearance White Powder
CAS 1802220-02-5
MF C13H11BrN2O
Repotrectinib is a small (low molecular weight), macrocyclic tyrosine kinase inhibitor of ROS1, TRK and ALK. Repotrectinib was designed to efficiently bind with the active kinase conformation and avoid steric interference from a variety of clinically resistant mutations. The compact and rigid three-dimensional structure enables repotrectinib to precisely and efficiently bind deep into the ATP binding pocket of the kinase, and potentially circumvent the steric interference that results in resistance to bulkier kinase inhibitors, especially the solvent-front and gatekeeper mutations of ROS1, TRK and ALK kinases.
Ropotrectinib is a next generation ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase.

Basic Info

Product Name:
Repotrectinib

Other Name:
Repotrectinib;TPX-0005;1802220-02-5;08O3FQ4UNP;TPX0005;UNII-08O3FQ4UNP;TRX-0005;Repotrectinib (USAN);Repotrectinib [USAN];(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one

CAS No.:
1802220-02-5

Molecular Formula:
C18H18FN5O2

InChIKeys:
FIKPXCOQUIZNHB-WDEREUQCSA-N

Molecular Weight:
355.4

Exact Mass:
355.14445300

UNII:
08O3FQ4UNP

NCI Thesaurus Code:
C133821

Categories:

Characteristics
Seller Information

Business Type:
Trader

Main Products:
API OLED Organic intermediate,1-Cyclopentene-1-carbonitrile,Cyclohexanol, 4-chloro-,1,3-Cyclohexanedione,2,2-Dimethyl-1,3-cyclohexanedione,6-Bromo-1,2,3,4-tetrahydroquinoline

Location:
No.8 Huangguang Road Qinhuai District Nanjing City Jiangsu China

Payment Terms:
TT against copy of documents,D/P,L/C,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2011

Active as a professionally chemicals supplier, Kindchem(Nanjing) Co.,Ltd ,established in 2011,located in Nanjing City,is committed to serve it's clients with a diverse range of chemicals.
We are specialized in the development and manufacture of electric chemicals including Liquid crystal OLED and OPV materials,pharmaceutical intermediates and other speciality chemicals.We are also engaged in Custom synthesis and contract manufacturing to meet the different requirements from clients worldwide.
Strengthened technical exchange and cooperation with surrounding universities and research institutes, we constantly enhanced its independent research and development capabilities and improved product quality by using the rich technology, information and resources from them, so as to guarantee the innovative development of enterprises.
Adhering to the business philosophy of being kind to people and friendly to the environment, the company strives for survival by quality and development by reputation. It is willing to cooperate with people of insight and new and old customers to grow together and contribute to the sustainable development of the chemical industry.
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Product Name	Ropotrectinib
Appearance	White Powder
CAS	1802220-02-5
MF	C13H11BrN2O

Reptectinib Crude

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