1-beta-D-Arabinofuranosylcytosine hydrochloride RC03270
69-74-9
Pharmaceutical Grade
99%
Royalchem
25kg/drum
2029-12-31
Pharmaceutical intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceCytarabine hydrochloride is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
Crystals (from aqueous ethanol) or fluffy white powder. (NTP, 1992)
Crystals (from aqueous ethanol) or fluffy white powder. (NTP, 1992)|Cytarabine Hydrochloride is the hydrochloride form of cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.|A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Basic Info-
Product Name:
Cytarabine hydrochloride
Other Name:2(1H)-Pyrimidinone,4-amino-1-β-D-arabinofuranosyl-,hydrochloride (1:1);Cytosine,1-β-D-arabinofuranosyl-,monohydrochloride;2(1H)-Pyrimidinone,4-amino-1-β-D-arabinofuranosyl-,monohydrochloride;U 19920A;1-β-D-Arabinofuranosylcytosine hydrochloride;Cytarabine hydrochloride;Cytosine arabinoside hydrochloride;Aracytidine hydrochloride;1-β-D-Arabinofuranosylcytosine monohydrochloride;Arabinofuranosylcytosine hydrochloride;Arabinosylcytosine hydrochloride;Spongocytidine-hydrochloride
CAS No.:69-74-9
Molecular Formula:C9H13N3O5.ClH
InChIKeys:InChIKey=KCURWTAZOZXKSJ-JBMRGDGGSA-N
Molecular Weight:279.68
Exact Mass:279.062195
EC Number:200-713-9
UNII:33K3DB6591
DSSTox ID:DTXSID5024891
NCI Thesaurus Code:C71603
HScode:2942000000
Categories:
Characteristics-
PSA:
129
XLogP3:-1.17980
Appearance:White to off-white crystalline
Melting Point:186-188 °C
Boiling Point:545.7°C at 760 mmHg
Flash Point:283.8ºC
Water Solubility:greater than or equal to 100 mg/mL at 63° F (NTP, 1992)
Storage Conditions:2-8°C
Toxicity:Peritoneal-rat LD50: 5500 mg/kg; oral-mouse LD50: 826 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxides and chloride fumes
Air and Water Reactions:Water soluble. Hydrolysis occurs readily, especially with acid.
Reactive Group:Alcohols and Polyols
Reactivity Profile:CYTARABINE HYDROCHLORIDE undergoes decomposition in acidic solutions.
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Eye irritation, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P264 Wash ... thoroughly after handling.
P203 Obtain, read and follow all safety instructions before use.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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