Supply Nootropic P21 Raw Powder

Name:  Lynn
Wechat：  15914422644

Tel：+86  15914422644

Whatsapp: +852 6252 8290

Email：    guangsheng 5   @zgguangsheng.com

I. Core Molecular Properties & Formulation

1. Molecular Specifications

   
   

   The peptide has a molecular formula of C30​H54​N6​O5​ and a molecular weight of 578.8 Da. Its core amino acid sequence is Ac-DGGL(A)G-NH₂, with the adamantane modification enabling BBB transit and resistance to degradation. Research-grade P21 typically has a purity of ≥98% (verified by HPLC and mass spectrometry).
   
   
2. Handling & Storage Guidelines

   
   

   Supplied as a sterile lyophilized white powder for laboratory use only. Store the unopened powder at -20°C in a desiccated, light-protected container to prevent peptide degradation. Avoid repeated freeze-thaw cycles. Reconstitute with sterile water or dimethyl sulfoxide (DMSO) to the desired concentration; the reconstituted solution should be used within 24–48 hours and stored at 2–8°C during this period.
   
   

II. Mechanism of Action

1. Neurotrophic & Neuroprotective Effects

   
   

   By mimicking the active domain of CNTF, P21 binds to CNTF receptors on neuronal cell membranes, activating downstream signaling cascades (e.g., JAK-STAT, MAPK/ERK). This promotes neuronal differentiation, supports synaptic plasticity, and reduces oxidative stress-induced neuronal damage. In preclinical models, it has demonstrated potential in mitigating cognitive decline and regulating abnormal tau protein, a hallmark of certain neurodegenerative conditions.
   
   
2. Cell Cycle Regulation

   
   

   As a functional cyclin-dependent kinase (CDK) inhibitor, P21 interacts with cyclin-CDK complexes (e.g., cyclin E-CDK2, cyclin D-CDK4/6) to block their kinase activity, inducing reversible cell cycle arrest at the G1 phase. It also binds to proliferating cell nuclear antigen (PCNA), inhibiting PCNA-dependent DNA replication and repair processes. This mechanism allows precise control of cell proliferation in in vitro and in vivo research models.
   
   

III. Key Research Applications

1. Neuroscience Research

   
   

   Used to investigate the role of CNTF signaling in neurodegenerative diseases, cognitive function maintenance, and neuronal repair after injury. It serves as a tool to validate CNTF receptor-mediated pathways and develop targeted neuroprotective strategies.
   
   
2. Cell Biology & Oncology Studies

   
   

   Applied in cell cycle regulation research to study G1 phase arrest mechanisms and their implications for cancer cell proliferation. It is also used to explore the interplay between cell cycle control and cellular stress responses (e.g., DNA damage, nutrient deprivation).
   
   
3. Peptide Drug Development

   
   

   Serves as a lead compound for designing next-generation neurotrophic peptide analogs with optimized pharmacokinetic properties, including enhanced BBB permeability and prolonged half-life.
   
   

IV. Safety & Research Precautions

1. P21 is strictly intended for laboratory research use, not for human or veterinary therapeutic applications.
2. Standard laboratory protective equipment (gloves, lab coat, safety goggles) should be worn during handling to avoid direct contact with skin and mucous membranes.
3. In case of accidental exposure, rinse the affected area with plenty of water and seek medical advice if irritation persists.
4. Dispose of unused peptide and waste materials in accordance with local laboratory chemical waste regulations.