PNC-27 CAS No.: 1159861-00-3, 99% purity, affordable price, factory direct sales

• • PNC-27 peptide is a polypeptide with a specific sequence and structure. Polypeptides participate in numerous important physiological processes in organisms, such as intercellular signaling, enzyme activity regulation, and immune responses. PNC-27 peptide may exert its unique biological functions by binding to specific receptors or molecules in the body. Current research has found that many polypeptides show great potential in disease treatment, such as as novel drugs for the treatment of cancer and neurodegenerative diseases. PNC-27 peptide may also have potential applications in related fields. Its research aims to explore new bioactive molecules, providing new tools and directions for disease treatment and life science research.

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• • • PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.

Jinan Zhiwen Xinsheng Electric Technology Co., Ltd. Was established in 2009. It mainly deals in peptide products, synthetic peptide amino acids, beauty and slimming products, and beauty freckle removal cosmetic raw materials. It has strong R&D capabilities, superb synthesis technology, and advanced quality control methods. It effectively promotes joint ventures with major companies and manufacturers, and serves the society and users with the concept of industrial development. It always adheres to market demand-oriented, continuously synthesizing new high-tech freckle and wrinkle removal beauty peptide products, which are mainly exported to the United States, Europe, South Africa, Nigeria and other countries and regions. It has rich export experience and ensures transportation safety. 

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Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.Mutual effort towards each other.

Why should you buy from us not from other suppliers?

1. Powerful R & D team
2. The ability of quantized production from grams to tons;
3. Various kinds of advanced equipment in the laboratory and plant;
4 .Strict QC standard to meet the demand of customers, advanced equipment for analysis and assay;
5. Efficient and safe logistic plans for chemical products transportation;
6 .Excellent after-sale service.
7. Highest quality and good package