Hot Selling Clindamycin HCl 99% CAS 21462-39-5 Clindamycin hydrochloride

Clindamycin is a lincosamide antibiotic widely used for treating various bacterial infections.

Mechanism of Action

Clindamycin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, specifically to the 23S rRNA. This binding interferes with ribosomal translocation and peptide bond formation, leading to a bacteriostatic effect, although at higher concentrations it can be bactericidal . Clindamycin's action is similar to that of macrolides and streptogramins, which share overlapping binding sites on the ribosome . Resistance to clindamycin can occur due to mutations in the rRNA or through cross-resistance with other antibiotics in its class

Applications

Clindamycin is effective against a range of infections, including:
Skin and Soft Tissue Infections: Effective for conditions like acne vulgaris and cellulitis.
Respiratory Tract Infections: Treats infections caused by streptococci and staphylococci.
Bone and Joint Infections: Used for osteomyelitis and septic arthritis.
Gynecological Infections: Treats bacterial vaginosis and pelvic inflammatory disease.
Intra-abdominal Infections: Effective against anaerobic bacteria associated with abscesses.
Severe Infections: Administered intravenously for serious conditions such as septicemia.

Routes of Administration

Oral Capsules: Commonly used for outpatient treatment.
Topical Formulations: Creams or gels used primarily for acne treatment.
Intravaginal Suppositories: Used for treating bacterial vaginosis.
Injectable Forms: Administered intravenously in hospital settings for severe infections.

Safety and Side Effects

Clindamycin may cause several side effects, some of which can be serious:
Common Side Effects: Nausea, vomiting, abdominal pain, diarrhea, and an unpleasant taste in the mouth.
Serious Risks: A significant concern is the potential for Clostridium difficile-associated diarrhea (CDAD), which can lead to pseudomembranous colitis. Symptoms may include severe diarrhea and abdominal cramping.
Hypersensitivity Reactions: Skin rashes, urticaria, and in rare cases, severe reactions like Toxic Epidermal Necrolysis or anaphylaxis have been reported.
Patients should be monitored for gastrointestinal symptoms during treatment, especially elderly patients who are at higher risk for complications from diarrhea.

Pharmacokinetics

Absorption and Distribution
Clindamycin is well absorbed from the gastrointestinal tract when taken orally. It achieves high tissue concentrations, particularly in bone and soft tissues. The drug is approximately 90% protein-bound in serum.
Metabolism
Clindamycin undergoes hepatic metabolism primarily via the cytochrome P450 system (CYP3A4), producing inactive metabolites such as clindamycin sulfoxide.
Elimination
The elimination half-life of clindamycin ranges from about 2.4 to 4 hours depending on age and health status. Approximately 10% of the drug is excreted unchanged in urine; most is eliminated as inactive metabolites in feces.
Special Considerations
Elderly patients may experience a slightly prolonged half-life but do not require dosage adjustments if they have normal liver function. Caution is advised when administering clindamycin alongside drugs that induce hepatic enzymes, as this may affect its clearance.

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Passion to innovate, Power to deliver !

Q1 Can i get some samples?

A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2 How to start orders or make payments?

A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Payment by T/T,or Paypal or Escrow(Alibaba).

Q3 How to confirm the Product Quality before placing orders?

A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

to us and take the samples. You can send us your product specifications and requests,we will manufacture

the products according to your requests.

Q4 What’s your MOQ?

A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

is 100% paid.

Q5 How about delivery leadtime?

A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6 Is there a discount?

A6 Different quantity has different discount.

Q7 How do you treat quality complaint?

A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

caused by us, we will send you free goods for replacement or refund your loss.

Q8 How to contact us ?

A8 You can choose your interested products and send inquiry to us.