Supplier: East Chemsources Limited (Factory Direct Supply)
Supply Type: Factory Direct | Best Competitive Price
Product Grade: High Purity (Laboratory & Research Use)
Revision Date: March 2026
Document No.: ECS-NACEE-59587-09-6
N-Acetyl-L-cysteine Ethyl Ester (NACEE) - Application Description
CAS No.: 59587-09-6
I. Core Characteristics (Basis of Applications)
NACEE is an esterified prodrug of N-Acetyl-L-cysteine (NAC). It retains the core sulfhydryl group (-SH) structure, and its ethyl ester group significantly enhances lipophilicity. Compared with regular NAC, NACEE penetrates cell membranes and the blood-brain barrier more easily, achieving higher cellular absorption rate and more efficient onset of action. It has close safety to NAC with good tolerability. Its core functions revolve around antioxidation and cytoprotection.
II. Main Applications (Categorized by Field)
1. Pharmaceutical Field (Core Application)
- Antioxidation & Cytoprotection: As a potent antioxidant, it directly scavenges free radicals and reactive oxygen species (ROS) in the body, reduces oxidative stress damage, and provides raw materials for intracellular glutathione (GSH) synthesis. It enhances the body's antioxidant capacity to protect cellular and mitochondrial functions.
- Hepatoprotection: It alleviates oxidative damage to liver cells caused by drugs, toxins, alcohol, etc., increases liver cell GSH levels, assists in improving liver metabolic function, and can be used in the development and production of hepatoprotective products.
- Neuroprotection: With excellent lip solubility, it can penetrate the blood-brain barrier, be used for neuro-oxidative stress and brain protection-related research and product development, support the maintenance of cognitive function, and assist in improving oxidative damage in the brain.
- Respiratory Application: It has the effect of diluting sputum and improving mucus viscosity. Meanwhile, it reduces oxidative stress and inflammation in the airway, with better effect than regular NAC. It can be used as a mucolytic agent for respiratory-related product formulations.
- Detoxification Assistance: It can be used as an auxiliary antidote for acetaminophen (paracetamol) poisoning, reduce the damage of drugs to the body, regulate transaminase levels in plasma, and reduce the physiological effects caused by poisoning.
- Potential Pharmaceutical Research: It has certain anti-inflammatory and anti-tumor activities, can inhibit protein synthesis, DNA replication and induce apoptosis. It is used in in vitro experiments and preclinical research in the field of drug development.
2. Cosmetic Field
- Antioxidant & Anti-aging: Scavenges free radicals on the skin surface, reduces light damage caused by ultraviolet rays and environmental factors, delays skin aging, and improves skin roughness and dullness, maintaining youthful skin condition.
- Skin Repair: Alleviates skin inflammatory reactions, promotes skin barrier repair, stabilizes the cellular environment related to collagen, assists in improving skin sensitivity and redness, and brightens skin tone and uneven skin color.
3. Healthcare & Sports Nutrition Field
- Sports Recovery: Reduces oxidative stress response in the body after exercise, alleviates muscle inflammation, relieves exercise-induced fatigue, assists in muscle recovery, and can be used in sports nutrition supplement formulations.
- Daily Healthcare: As an antioxidant health ingredient, it assists in improving the body's immunity, reduces damage to cells caused by free radicals, and is suitable for the development and production of various dietary supplements and health products. It can also be used as an endogenous hydrogen sulfide (H₂S) donor to regulate the body's physiological functions.
4. Scientific Research Field
Widely used in scientific research such as biomedicine and pharmacology. It is used as a cell protectant and antioxidant model for research on oxidative stress, cell damage and repair, neuroprotection and other topics, and is suitable for in vitro cell experiments, animal experiments and other scenarios, providing basic raw material support for related research.
III. Supplementary Notes
- Copy the full text into Word, adjust font and line spacing directly without deleting redundant content, suitable for Word editing requirements;
- The application description is closely based on actual application scenarios, balancing professionalism and understandability, and can be directly used for product instructions, customer communication, file archiving and other scenarios;
- The core applications are based on product characteristics, referring to the general application standards in the industry to ensure the accuracy and comprehensiveness of information.
1. Product Identification
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- English Product Name: N-acetylcysteine Ethyl Ester from factory East Chemsources-best price
- English Synonyms: Ethyl (2R)-2-acetamido-3-sulfanylpropanoate; Ethyl N-acetyl-L-cysteinate
- CAS No.: 59587-09-6
- Chemical Formula: C₇H₁₃NO₃S
- Molecular Weight: 191.25 g/mol
- Chemical Class: Amino acid derivative
- Appearance: White powder
- Solubility: Soluble in ethanol, methanol and other organic solvents; slightly soluble in water
2. Technical Specifications
| Parameter | Specification |
| Purity (HPLC) | ≥ 98.0% |
| Moisture | ≤ 0.5% |
| Melting Point | 60-65 °C |
| Specific Rotation ([α]²⁰/D) | -28° to -32° (c=1, ethanol) |
| Heavy Metals (as Pb) | ≤ 10 mg/kg |
| Residue on Ignition | ≤ 0.1% |
3. Physical & Chemical Properties
- Stability: Stable under normal storage conditions; avoid contact with oxidants, strong acids and strong alkalis
- Hazard Classification: Non-hazardous for transport; for laboratory and research use only
- Flash Point: ≥ 110 °C (non-flammable solid)
- Odor: Slight characteristic odor
4. Applications
For laboratory and scientific research use only in legal and non-patented regions (export only). It is an important amino acid derivative, widely used in biochemical research, pharmaceutical intermediate research and development, and organic synthesis research.
5. Packaging & Storage
- Packaging: 1kg/bag (aluminum foil bag); 25kg/barrel (fiber drum with inner PE bag)
- Storage Conditions: Store in a closed, dry, room temperature environment, away from direct sunlight; keep sealed tightly to prevent moisture absorption and oxidation.
- Shelf Life: 24 months under proper storage conditions (unopened package)
- Transport: Non-hazardous for transport; avoid collision, rain and moisture during transit; separate from oxidants and corrosive substances.
6. Safety & Handling
- Personal Protection: Wear protective gloves and goggles when handling; avoid inhalation of dust and contact with skin/eyes.
- Handling Precautions: Operate in a well-ventilated environment; do not mix with oxidants, strong acids or strong alkalis.
- Spill Handling: Collect spilled powder with inert material (e.g., sand), seal in a container, and dispose of according to local regulations.
- First Aid: In case of eye contact, flush with water for 15+ minutes; if skin irritation occurs, rinse with water; seek medical attention if necessary.
7. Important Notes
All products of our company are for export only, and are used for laboratory and scientific research in legal and non-patented regions. It is strictly prohibited for personal or animal use. Illegal abusers shall bear full responsibility for the consequences arising therefrom.
8. Supply Information
- Supplier: East Chemsources Limited (Factory Direct Supply, no middlemen)
- Price: Best competitive factory price (bulk order discounts available)
- Quality Assurance: Strict quality control, COA (Certificate of Analysis) provided per batch
- MOQ: 1kg (small batch acceptable; bulk order available)
- Lead Time: 7–15 days (stock available for regular specifications)
- Payment Terms: T/T (30% deposit, 70% before shipment), L/C at sight
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