Cytarabine
1 Inquiries
147-94-4
Chemical Grade
99%
Wuhan pnq
Aluminum foil bag
2030-03-24
Apigenin,PQQ,NMNH
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceCytarabine is a chemotherapy drug used to treat acute myeloid leukaemia, acting by inhibiting DNA synthesis with an IC50 of 16 nM.
Cytarabine appears as colorless crystals. Used as an antiviral agent.|Solid
Cytarabine appears as colorless crystals. Used as an antiviral agent.|Cytarabine is a pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties. It has a role as an antineoplastic agent, an antimetabolite, an antiviral agent and an immunosuppressive agent. It is a beta-D-arabinoside, a pyrimidine nucleoside and a monosaccharide derivative. It derives from a cytosine.|A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)|Cytarabine is a Nucleoside Metabolic Inhibitor. The mechanism of action of cytarabine is as a Nucleic Acid Synthesis Inhibitor.|Cytarabine is a cytosine analogue and antineoplastic agent used largely in the therapy of acute leukemia. Cytarabine is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has only rarely been implicated in cases of clinically apparent acute liver injury with jaundice.|Cytarabine is an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. (NCI04)Basic Info-
Product Name:
Cytarabine
Other Name:2(1H)-Pyrimidinone,4-amino-1-β-D-arabinofuranosyl-;Cytosine,1-β-D-arabinofuranosyl-;4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone;4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine;1-(Arabinofuranosyl)cytosine;Cytarabine;Aracytidine;ara-Cytosine;1-β-D-Arabinosylcytosine;1-β-Arabinofuranosylcytosine;(Arabinofuranosyl)cytosine;Cytosine β-D-arabinofuranoside;Cytosar;Cytarabinoside;U 19920;Ara-C;NSC 63878;Ac 1075;U 19920A;Cytarabin;Spongocytidine;Alexan;Cyclocide;Cytosine-1-β-arabinofuranoside;Cytosine-1-β-D-arabinofuranoside;1-(β-D-Arabinofuranosyl)cytosine;Cytosine β-D-arabinoside;Aracytin;Cytosine arabinoside;Arafcyt;Arabinocytosine;Arabinoside C;Citozar;Udicil;DepoCyte;Aracytine;Iretin;NSC 287459;Cytosar U;CHX 3311;Arabitin;Erpalfa;Tarabine PFS;Ara-cell;Cylocide;DepoCyt;Cylocide N;4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;MK 8242;SCH 900242
CAS No.:147-94-4
Molecular Formula:C9H13N3O5
InChIKeys:InChIKey=UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Molecular Weight:243.22
Exact Mass:243.22
EC Number:205-705-9
UNII:04079A1RDZ
DSSTox ID:DTXSID3022877
NCI Thesaurus Code:C408
Color/Form:Prisms from 50% ethanol|WHITE TO OFF-WHITE CRYSTALLINE POWDER
ATC Code:L01XY01|L01BC01|L - Antineoplastic and immunomodulating agents
HScode:29349990
Categories:
Characteristics-
PSA:
129
XLogP3:-2.1
Appearance:crystalline
Density:1.9±0.1 g/cm3
Melting Point:212-213 °C
Boiling Point:545.7ºC at 760 mmHg
Flash Point:274.1±32.9 °C
Refractive Index:1.756
Water Solubility:H2O: almost transparency;H2O: 50 mg/mL, clear, colorless
Storage Conditions:2-8°C
Vapor Pressure:8.74X10-12 mm Hg at 25 deg C (est)
Toxicity:Oral-rat LD50: > 5000 mg/kg; Oral-Mouse LD50: 3150 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
Specific rotation:D24 +153° (c = 0.5 in water)
Odor:ODORLESS
Henrys Law Constant:Henry's Law constant = 1.57X10-19 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 4.22
Collision Cross Section:150.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:NON-HYGROSCOPIC @ 40 °C|Hydroxyl radical reaction rate constant = 1.23X10-10 cu cm/molec-sec at 25 °C (est)
Air and Water Reactions:Water soluble.
Reactive Group:Alcohols and Polyols
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H317 May cause an allergic skin reaction
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Apigenin,PQQ,NMNH
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Location:
Room 1006, Building C6, Economic Development Wanda, Caidian District, Wuhan City, Hubei Province
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Payment Terms:
100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
Less than $1 million
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Total Employees:
5-10
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Year of Establishment:
2021
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Cytarabine
120 G May 2, 2025 Post an enquiry for this product
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