Bengenin Microglial Activation Blocker: Suppresses Pro-Inflammatory Cytokine Release in Neuroinflammation Models

1.Description

Bergenin, also known as dwarf catechin, is a needle shaped or crystalline powder extracted from the whole plant of Bergenia purpurscens   (Hook.f.et Thoms.)   Engl. in the family Saxifragaceae. Bergenin is a new variety in the 2015 Pharmacopoeia. It is mainly produced in Sichuan, Yunnan, Xizang and other places. Harvesting in spring and autumn, washing away sediment, removing decayed leaves from roots, and drying in the sun.

2.Application

（1）Antitussive effect: Bergenin exerts its antitussive effect by inhibiting the cough center, thereby reducing the cough reflex. Its mechanism lies in selectively inhibiting the cough center without significantly enhancing the inhibition of other central nervous system functions, which is different from opioid-based central antitussive drugs.

（2）Antibacterial: It can effectively inhibit the growth of various bacteria, including Staphylococcus aureus, Escherichia coli, Shigella, and Pseudomonas aeruginosa. It primarily achieves its antibacterial effect by blocking bacterial cell wall synthesis and disrupting their living environment.

（3）Anti-inflammatory: Bergenin is capable of reducing the production of inflammatory mediators, thereby lowering the inflammatory response of tissues.

（4）Antitumor effect: Bergenin exhibits significant inhibitory effects on certain types of tumor cells, such as gastric cancer, liver cancer, and lung cancer. It achieves its antitumor effect by inducing tumor cell apoptosis and inhibiting tumor cell proliferation, while simultaneously enhancing the body's immune function and improving its ability to combat tumors.

3.Application fields

（1）Pharmaceutical Field:

Clinical Applications: Bergenin is primarily used in the treatment of respiratory diseases such as chronic bronchitis, emphysema, pulmonary heart disease, bronchial asthma, and others. Its pharmacological effects include antitussive, expectorant, anti-inflammatory, and antibacterial properties.

Mechanism of Action: It alleviates cough symptoms by inhibiting the cough center in the central nervous system and reducing the sensitivity of the cough reflex. It promotes the discharge of respiratory mucosal secretions to help clear phlegm. It also alleviates pain and discomfort caused by respiratory inflammation by reducing the inflammation.

（2）Health Supplement Field:

Health Benefits: Bergenin has potential health benefits such as enhancing immunity and improving metabolism, which can be utilized in the development of health supplements.

Market Applications: As a component in health supplements, Bergenin can be used to prevent or alleviate respiratory diseases and improve overall health.

（3）Cosmetic Field:

Skincare Efficacy: Bergenin has antioxidant, whitening, acne-clearing, and anti-inflammatory effects, which can be applied in cosmetic development.

Product Examples: Cosmetics containing Bergenin can be used to reduce skin pigmentation, remove spots and freckles, and improve skin condition.

4. Packing & Shipping

Generally, the Bergenin  will be packed in two plastic bags and one foil bag, and then a fiber drum for 25kg.