High Quality Liothyronine sodium Raw Powder CAS 55-06-1

Liothyronine sodium presents as a light tan to buff-colored crystalline powder with a characteristic faint amine-like odor. The compound exhibits hygroscopic properties, readily absorbing moisture from the atmosphere when exposed. It demonstrates good solubility in aqueous alkaline solutions (pH >8) and limited solubility in neutral or acidic aqueous media. The crystalline structure shows needle-like morphology under microscopic examination. Stability studies indicate optimal preservation when stored in airtight containers protected from light at controlled room temperature (15-30°C), with degradation occurring upon prolonged exposure to heat, moisture, or strong light sources. The material typically has a bulk density of 0.5-0.7 g/cm³ and may show slight clumping under humid conditions.

Introduction

As a synthetic sodium salt of the endogenous thyroid hormone triiodothyronine (T3), liothyronine sodium represents a potent thyroid hormone replacement agent. The compound's molecular structure features three iodine atoms at specific positions on the thyronine backbone, which are critical for its biological activity. In physiological systems, it binds to nuclear thyroid hormone receptors with high affinity, modulating gene expression and influencing metabolic processes throughout the body. Compared to thyroxine (T4), it demonstrates more rapid onset of action and shorter duration of effect due to differences in protein binding and metabolic clearance. The sodium salt formulation was developed to enhance stability and improve water solubility for pharmaceutical applications.

Source

Liothyronine sodium is exclusively manufactured through multi-step synthetic organic processes starting from thyronine derivatives. The production involves careful iodination reactions under controlled conditions, followed by purification through crystallization and salt formation. Commercial production occurs in GMP-certified facilities with strict controls over temperature, pH, and reaction times to ensure consistent quality. The synthetic route typically yields material with ≥98% purity by HPLC, with specifications for residual solvents, heavy metals, and related substances meeting pharmacopeial standards. For research use, it's available through pharmaceutical chemical suppliers in quantities ranging from grams to kilograms, accompanied by comprehensive analytical documentation.

Uses

In clinical medicine, liothyronine sodium serves as replacement therapy for hypothyroid conditions, particularly in cases requiring rapid thyroid hormone effect. It's specifically indicated for myxedema coma, congenital hypothyroidism, and T3 suppression testing. The compound finds additional application in psychiatric practice as an adjunct in refractory depression treatment. Beyond therapeutic uses, it's employed in research settings to study thyroid hormone signaling pathways, metabolic regulation, and cardiac function. Specialized applications include its use in diagnostic medicine for thyroid function assessment and in veterinary medicine for treating feline hyperthyroidism when compounded with other agents.

Applications

Therapeutic applications include:

Acute management of life-threatening hypothyroidism

Short-term replacement therapy during transitions from IV to oral medication

Adjunctive treatment in thyroid cancer suppression therapy

Psychiatric augmentation strategies for treatment-resistant mood disorders

Research applications encompass:

Studies of thyroid hormone receptor activation kinetics

Investigations into metabolic rate regulation

Cardiovascular research examining inotropic and chronotropic effects

Developmental biology studies of thyroid hormone-dependent processes

Diagnostic uses involve:

T3 suppression testing for autonomous thyroid function evaluation

Radioactive uptake studies when labeled with appropriate isotopes

Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
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