99% Liothyronine sodium 55-06-1

Liothyronine sodium More Info

Liothyronine sodium presents as a light tan to buff-colored crystalline powder with a characteristic faint amine-like odor. The compound exhibits hygroscopic properties, readily absorbing moisture from the atmosphere when exposed. It demonstrates good solubility in aqueous alkaline solutions (pH >8) and limited solubility in neutral or acidic aqueous media. The crystalline structure shows needle-like morphology under microscopic examination. Stability studies indicate optimal preservation when stored in airtight containers protected from light at controlled room temperature (15-30°C), with degradation occurring upon prolonged exposure to heat, moisture, or strong light sources. The material typically has a bulk density of 0.5-0.7 g/cm³ and may show slight clumping under humid conditions.

Introduction

As a synthetic sodium salt of the endogenous thyroid hormone triiodothyronine (T3), liothyronine sodium represents a potent thyroid hormone replacement agent. The compound's molecular structure features three iodine atoms at specific positions on the thyronine backbone, which are critical for its biological activity. In physiological systems, it binds to nuclear thyroid hormone receptors with high affinity, modulating gene expression and influencing metabolic processes throughout the body. Compared to thyroxine (T4), it demonstrates more rapid onset of action and shorter duration of effect due to differences in protein binding and metabolic clearance. The sodium salt formulation was developed to enhance stability and improve water solubility for pharmaceutical applications.

Source

Liothyronine sodium is exclusively manufactured through multi-step synthetic organic processes starting from thyronine derivatives. The production involves careful iodination reactions under controlled conditions, followed by purification through crystallization and salt formation. Commercial production occurs in GMP-certified facilities with strict controls over temperature, pH, and reaction times to ensure consistent quality. The synthetic route typically yields material with ≥98% purity by HPLC, with specifications for residual solvents, heavy metals, and related substances meeting pharmacopeial standards. For research use, it's available through pharmaceutical chemical suppliers in quantities ranging from grams to kilograms, accompanied by comprehensive analytical documentation.

Uses

In clinical medicine, liothyronine sodium serves as replacement therapy for hypothyroid conditions, particularly in cases requiring rapid thyroid hormone effect. It's specifically indicated for myxedema coma, congenital hypothyroidism, and T3 suppression testing. The compound finds additional application in psychiatric practice as an adjunct in refractory depression treatment. Beyond therapeutic uses, it's employed in research settings to study thyroid hormone signaling pathways, metabolic regulation, and cardiac function. Specialized applications include its use in diagnostic medicine for thyroid function assessment and in veterinary medicine for treating feline hyperthyroidism when compounded with other agents.

Applications

Therapeutic applications include:

Acute management of life-threatening hypothyroidism

Short-term replacement therapy during transitions from IV to oral medication

Adjunctive treatment in thyroid cancer suppression therapy

Psychiatric augmentation strategies for treatment-resistant mood disorders

Research applications encompass:

Studies of thyroid hormone receptor activation kinetics

Investigations into metabolic rate regulation

Cardiovascular research examining inotropic and chronotropic effects

Developmental biology studies of thyroid hormone-dependent processes

Diagnostic uses involve:

T3 suppression testing for autonomous thyroid function evaluation

Radioactive uptake studies when labeled with appropriate isotopes

Precautions

Critical safety considerations include:

Cardiovascular monitoring: Requires careful titration in patients with preexisting heart disease due to risk of arrhythmias and angina

Metabolic effects: May exacerbate diabetes mellitus or adrenal insufficiency

Dosing precision: Narrow therapeutic index necessitates accurate dosing based on serum hormone levels

Drug interactions: Caution with anticoagulants (potentiated effects), antidepressants (possible synergistic effects), and cholestyramine (reduced absorption)

Storage requirements: Maintain in original containers with desiccants, protected from light and moisture

Occupational handling: Use appropriate PPE to prevent inhalation or dermal exposure during weighing

Patient monitoring: Regular assessment of thyroid function tests, cardiac status, and bone density in long-term use

Special populations: Reduced dosing required in elderly patients and those with prolonged hypothyroidism

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.