Adipotide CAS 859216-15-2 Peptides Factory Supply Weight Loss raw materials

      Adipotide is a synthetic peptide specifically designed to precisely target the blood vessels in adipose tissue and induce their apoptosis. It has shown potential in the research field of obesity and related metabolic diseases.

      Adipotide, also known as Fat Targeted Apoptosis Peptide (FTPP), is a complex chimeric peptide. Its complete sequence is CKGGRAKDC-GG-D(KLAKLAK)₂.
      This molecule consists of three functional modules: the N-terminal cyclic peptide domain is responsible for specifically targeting fat blood vessels, the middle flexible connecting region, and the C-terminal pro-apoptotic functional domain.
Its CAS number is 859216-15-2. It is usually provided in a white or off-white powder form, with a purity specification of up to 98%.
      This product is currently positioned for research purposes only and is not for human use.

      Core efficacy and mechanism of action
    The core efficacy of Adipotide lies in its potent and selective reduction of adipose tissue, particularly visceral fat, which leads to a series of metabolic improvements.
    1. Precise targeting and fat reduction
    Adipotide specifically recognizes and binds to the highly expressed membrane protein Annexin A2 on the vascular endothelial cells of adipose tissue through its N-terminal cyclic peptide domain, achieving highly organ-selective action. After binding, the polypeptide is internalized into the cells, and its C-terminal KLAKLAK domain targets the mitochondria, disrupting the membrane potential and initiating the cell apoptosis program.
This leads to the collapse of the microvascular network in adipose tissue, cutting off the blood supply to adipocytes, causing them to "starve" and be reabsorbed by the body, thereby achieving fat reduction. Animal experiments have shown that in rat models, a 30% weight reduction can be achieved, and in obese rhesus monkeys, an average weight loss of 11% and a 39% reduction in fat deposition can be observed.

    2. Improve Metabolism
    As it can prioritize the reduction of visceral fat, Adipotide shows potential in improving metabolic syndrome. Its effects include enhancing insulin sensitivity, lowering blood sugar and lipid levels, and having an improving effect on non-alcoholic fatty liver disease.
The reduction of fat tissue is also accompanied by the alleviation of chronic inflammation, which helps to fundamentally improve metabolic diseases.

    3. Safety Characteristics
    Based on its mechanism of action, Adipotide is considered to have high targeted safety. It mainly acts on fat vessels and has minimal impact on the blood vessels of normal tissues such as muscles, heart, and brain. As a polypeptide, it can ultimately be metabolized into amino acids in the body. No significant reports of liver, kidney, neurotoxicity or cardiovascular toxicity were observed in animal experiments.

     Hongbai Technology Co., Ltd. is  a branch of Changsha Dolo Technology Co., Ltd.，which is a pioneering force in the biotechnology sector.

     At the core of our operations is the unwavering commitment to our guiding principles : "Quality First, Service Supreme."Our mission is to spearhead advancements in biotechnology by consistently upholding the highest standards of quality and service. Through innovation and excellence, we aim to contribute to the betterment of global health and well-being.

     Our primary focus encompasses a range of products , including weight loss peptides, cosmetic peptides, and customized peptides. Notable among our weight loss peptide offerings are Tirzepatide, Retatrutide, and others.Provides reliable and timely custom manufacturing services for API following stringent quality system and close communication with the Clients.We have professional sales team , focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market, our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.

     With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.