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Home > Active Pharmaceutical Ingredients > Veterinary Raw Materials > Pyrimethamine for Sale > High Quality Veterinary Grade CAS 58-14-0 Pyrimethamine Powder
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High Quality Veterinary Grade CAS 58-14-0 Pyrimethamine Powder

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Unit Price: Get Latest Price
CAS No.:

58-14-0

Grade:

Veterinary grade

Content:

99%

Port:

shanghai

Brand:

HNB

Packaging:

25kg Cardboard Drum

Price valid (until):

2026-05-01

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

  • Product Description

  • Seller Information

  • Description


      Product Description  


    What is Pyrimethamine  ?
    Pyrimethamine, also known as immortal, darapirin, is a broad-spectrum veterinary drug widely used for antiprotozoal. In addition, pyrimethamine is also used in aquatic products to enhance the disease resistance of aquatic fish. However, the side effects of pyrimethamine are relatively large. Excessive use can damage the reproductive system of livestock and poultry and is not easy to recover. Pyrimethamine has an inhibitory effect on the primary infrared stage of certain falciparum malaria and vivax malaria, and is a better preventive medicine. Although it has no obvious effect on the gametophytes of malaria parasites, the drug-containing blood enters the mosquitoes, which can affect the development of the gametophytes in the mosquitoes, so it can block transmission.
    Pyrimethamine  is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.
    This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. Pyrimethamine is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection.


    Pyrimethamine (Daraprim) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. It is also currently being evaluated in clinical trials as a treatment for ALS. In 2011, researchers have discovered that Pyrimethamine can increase ß-hexosaminidase activity, thus slowing down the progression of Late-Onset Tay-Sachs disease.

     

    Items Specifications
    Name Pyrimethamine
    CAS  58-14-0
    Molecular formula C12H13ClN4
    Density 248.71


      About Us


    Xian Harmonious Natural Bio- Technology Co., Ltd was founded in 2017, and located in Xian International Logistics Industrial Zone, Xian City. Shaanxi Province, China. Now it is the leading researcher and one of the biggest manufacturer in high technology APl area.

    There are 8 experts in our research team. We insistin innovation and produce high quality products. And GMP standard workshop and complete stainless extraction equipment.

    We have 2 sales deparments over 20 people and sell our products allover the word. We also have strong professional research and development team talented personnel and completely equipped laboratoy for the quality controlling. Various Detection Device is equipped in HNB company, such as HPLCGC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
    HNB mainly engaged in export of products incuding,without limitation., pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids minerals, peptides, plant extract, feed and food additives. Our company's business is based on Honest, Trustwortly, Constanty to Go Beyond and Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
    Passion to innovate, Power to deliver !

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      FAQ 


    Q1 Can i get some samples?

    A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.

    Q2 How to start orders or make payments?

    A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

    Payment by T/T,or Paypal or Escrow(Alibaba).

    Q3 How to confirm the Product Quality before placing orders?

    A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier

    to us and take the samples. You can send us your product specifications and requests,we will manufacture

    the products according to your requests.

    Q4 What’s your MOQ?

    A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge

    is 100% paid.

    Q5 How about delivery leadtime?

    A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

    Q6 Is there a discount?

    A6 Different quantity has different discount.

    Q7 How do you treat quality complaint?

    A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem

    caused by us, we will send you free goods for replacement or refund your loss.

    Q8 How to contact us ?

    A8 You can choose your interested products and send inquiry to us.

    Certificates

    Basic Info
    Product Name:

    Pyrimethamine

    Other Name:

    2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;Pyrimidine,2,4-diamino-5-(p-chlorophenyl)-6-ethyl-;5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;4753 R.P.;BW 50-63;Chloridin;Chloridine;Darapram;Daraprim;2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine;Malocide;Pyrimethamine;Daraprime;5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine;2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine;Darachlor;Malocid;Pirimetamin;Tindurin;Khloridin;Malacid;Pyrimethamin;Pirimecidan;Diaminopyritamin;Erbaprelina;NSC 3061;WR 2978;RP 4753;Tinduring

    CAS No.:

    58-14-0

    Molecular Formula:

    C12H13ClN4

    InChIKeys:

    InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N

    Molecular Weight:

    248.71

    Exact Mass:

    248.71

    EC Number:

    200-364-2

    UNII:

    Z3614QOX8W

    NSC Number:

    757306|3061

    UN Number:

    2811

    DSSTox ID:

    DTXSID9021217

    NCI Thesaurus Code:

    C788

    Color/Form:

    Crystals|White scored tablets contains 25 mg pyrimethamine /Daraprim/

    ATC Code:

    P01BD01|P - Antiparasitic products, insecticides and repellents

    HScode:

    2933599090

    Characteristics
    PSA:

    77.8

    XLogP3:

    2.7

    Appearance:

    Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.

    Density:

    1.4±0.1 g/cm3

    Melting Point:

    233.5 °C

    Boiling Point:

    491.5°C at 760 mmHg

    Flash Point:

    176.6±30.7 °C

    Refractive Index:

    1.667

    Water Solubility:

    H2O: <0.01 g/100 mL at 21 ºC

    Storage Conditions:

    0-6°C

    Vapor Pressure:

    1.32X10-8 mm Hg at 25 deg C (est)

    Toxicity:

    LD50 oral in rat: 440mg/kg

    PKA:

    7.34(at 20 °C)

    Henrys Law Constant:

    Henry's Law constant = 1.08X10-10 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    7.34 (at 20 °C)|pKa = 7.34 at 20 °C (conjugate acid)

    Collision Cross Section:

    155.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec at 25 °C (est)

    Air and Water Reactions:

    Insoluble in water.

    Reactive Group:

    Amines, Phosphines, and Pyridines

    Reactivity Profile:

    PYRIMETHAMINE is sensitive to exposure to light (NTP, 1992). Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store at 15 deg to 25 deg C (59 deg to 77 deg F) in a dry place and protect from light.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive

    Location:

    6 floor Baoyilongji Building B Weiyang Area, Fengcheng 8 Road, Xi'an city, Shaanxi, 710000, China

    Payment Terms:

    L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    51-100

    Year of Establishment:

    2017

    Certifications:

    ISO,ISO

    Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian

    International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is the

    leading researcher and one of the biggest manufacturer in high technology API area. 

     

    There are 8 experts in our research team. We insist in innovation and produce high quality

    products. And GMP standard workshop and complete stainless extraction equipment. 

    We have 2 sales departments over 20 people and sell our products all over the world.

     

    We also have strong professional research and development team, talented personnel and

    completely equipped laboratory for the quality controlling. Various Detection Device is

    equipped in HNB company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto

    titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

     

    HNB mainly engaged in export of products including, without limitation, pharmaceutical raw

    materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant

    extract, feed and food additives.

     

    Our company's business is based on Honest, Trustworthy, Constantly to Go Beyond and

    Achieve Mutual Win. Sincerely hope to strengthen exchanges and cooperation with friends

    from both home and abroad.

     

    Passion to innovate, Power to deliver !

  • Country Product Purchase Quantity Date Posted
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