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2-Chloro-5-aminobenzotrifluoride

Name: 2-Chloro-5-aminobenzotrifluoride
Brand: Chongqing Yuhan Technology Co., Ltd.
SKU: pr2604022018
Price: 200 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

320-51-4

Grade:

High Purity Grade

Content:

98%

Port:

Shanghai

Brand:

Chongqing Yuhan Technology Co., Ltd.

Packaging:

5g/bottle or 25kg/drum

Price valid (until):

2026-05-03

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Chongqing Yuhan Technology Co., Ltd

Company Type:

Trader

Location:

China

Qualification:

Main Products:

CARBONOCHLORIDOTHIOIC ACID,5-OCTYLESTER

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Product Description
Seller Information

Description

Product Detail

2-Chloro-5-aminobenzotrifluoride (CAS: 320-51-4), also known as 2-Amino-5-chlorobenzotrifluoride or 4-Chloro-3-trifluoromethylaniline, is an important organic intermediate widely used in pharmaceutical, agrochemical, and dye industries . This compound has the molecular formula C₇H₅ClF₃N and a molecular weight of 195.57 g/mol .

Chemical & Physical Properties
The product appears as a white to pink crystalline powder with a melting point of 35-37°C and a boiling point of 85°C at 3 mmHg . It has a density of 1.425 g/cm³ and is soluble in organic solvents. Commercial grades offer 98-99% purity .

Key Applications

Pharmaceutical Synthesis: It serves as a crucial intermediate in the production of Sorafenib, a multi-kinase inhibitor used for treating liver, kidney, and thyroid cancers.
Agrochemicals: It is widely used as a building block for herbicides, insecticides, and fungicides, with the trifluoromethyl group enhancing metabolic stability.
Dye Manufacturing: Known as Fast Scarlet VD Base, it is used in textile printing and dyeing, providing excellent lightfastness .

Storage & Handling
This product is classified as a hazardous substance (UN2811, Class 6.1) and should be stored in a cool, dry, well-ventilated area, away from oxidizing agents . Standard packaging includes 25g, 100g, 500g, and bulk quantities.

Items	Specifications
Key Intermediate for Sorafenib (Anticancer Drug)	This compound serves as a crucial building block in the synthesis of Sorafenib, a well-known multi-kinase inhibitor used for treating liver, kidney, and thyroid cancers . The presence of both chlorine and trifluoromethyl groups on the aromatic ring provides the structural framework necessary for the drug's biological activity. As an intermediate in pharmaceutical manufacturing, it is produced at metric ton scale, supporting commercial production of this life-saving medication.
Versatile Building Block for Agrochemicals and Dyes	Beyond pharmaceutical applications, 2-chloro-5-aminobenzotrifluoride is widely utilized as an intermediate in the synthesis of herbicides, insecticides, and fungicides . The trifluoromethyl group (-CF₃) is particularly valued in agrochemistry for enhancing metabolic stability and lipophilicity of active ingredients. Additionally, it serves as a precursor for azo dyes used in textile printing and dyeing, offering excellent lightfastness and color brilliance .
Halogenated Aromatic Amine with Unique Physical Properties	This compound belongs to the class of halogenated aromatic amines. It has a molecular formula of C₇H₅ClF₃N and a molecular weight of 195.57 g/mol . It appears as a white to pink crystalline powder with a melting point of 35-37°C . The presence of electron-withdrawing chlorine and trifluoromethyl groups, combined with the electron-donating amino group, creates a polarized aromatic system that facilitates further chemical transformations, making it an invaluable synthetic intermediate .

Basic Info

Product Name:

4-Chloro-3-(trifluoromethyl)aniline

Other Name:

Benzenamine,4-chloro-3-(trifluoromethyl)-;m-Toluidine,4-chloro-α,α,α-trifluoro-;4-Chloro-3-(trifluoromethyl)benzenamine;4-Chloro-3-(trifluoromethyl)aniline;3-(Trifluoromethyl)-4-chloroaniline;4-Chloro-α,α,α-trifluoro-m-toluidine;5-Amino-2-chlorobenzotrifluoride;3-Amino-6-chlorobenzotrifluoride;NSC 61405;(4-Chloro-3-trifluoromethylphenyl)amine;2-Chloro-5-aminobenzotrifluoride;3-Trifluoromethyl-4-chlorophenylamine

CAS No.:

320-51-4

Molecular Formula:

C7H5ClF3N

InChIKeys:

InChIKey=ASPDJZINBYYZRU-UHFFFAOYSA-N

Molecular Weight:

195.57

Exact Mass:

195.57

BRN:

641588

EC Number:

206-277-6

UNII:

000N5814MR

NSC Number:

61405

DSSTox ID:

DTXSID7059804

HScode:

29214300

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

3.5

Appearance:

White to pinkish or slightly orange Crystalline Powder or Low Melting Solid

Density:

1.4±0.1 g/cm3

Melting Point:

36-37 °C

Boiling Point:

132 °C @ Press: 27 Torr

Flash Point:

>230 °F

Refractive Index:

1.500

Storage Conditions:

Refrigerator

See More 4-Chloro-3-(trifluoromethyl)aniline Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-Chloro-3-(trifluoromethyl)aniline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
CARBONOCHLORIDOTHIOIC ACID,5-OCTYLESTER

Location:
B9-2, LIANGFENG COMMUNITY, CHANGSHENGQIAO TOWN, NANAN DISTRICT, CHONGQING CITY,CHINA

Payment Terms:
TT against copy of documents,D/P,L/C

Average lead Time:
60

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2017

Certifications:
GSG,Awards,Certificate of Record for the Handling of Non-Pharmaceutical Precursor Chemicals, Category II,Certificate of Registration for Entities Handling Explosive Hazardous Chemicals,Registration form for foreign trade operators,Hazardous Chemicals Operating License,Certificate of Record for the Handling of Non-Pharmaceutical Precursor Chemicals, Category III,Customs Receipt of Registration for Import/Export Consignees and Consignors,Business License
Country Product Purchase Quantity Date Posted

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