9-Methyl-9H-beta-carboline (9-Me-BC, CAS 2521-07-5) High Purity Nootropic Raw Material Powder for Laboratory Research and Neuropharmacology Study

9-Methyl-9H-beta-carboline More Info

9-Methyl-9H-beta-carboline, also known as 9-methyl-β-carboline or 9-Me-BC, is a heterocyclic amine belonging to the beta-carboline family of organic compounds. This family is characterized by a fused bicyclic structure containing both and indole moieties, and the addition of a methyl group at the 9-position distinguishes this derivative from the parent β-carboline (norharmane). With the molecular formula C12H10N2 and a molecular weight of approximately 182.22 g/mol, this compound exists as a solid powder or crystalline material, typically appearing white to yellow to green in color .

The compound exhibits well-defined physicochemical properties that are important for laboratory handling and research applications. It has a predicted density of approximately 1.17 g/cm³, a boiling point around 367°C, and a melting point range between 105°C and 109°C . The solubility profile includes DMF and DMSO at concentrations of 20 mg/ml, with limited aqueous solubility in PBS-based solutions. The compound demonstrates fluorescence properties with a maximum wavelength (λmax) of 361 nm in, which makes it potentially useful in certain analytical and detection applications .

The primary mechanism of action for 9-methyl-β-carboline involves inhibition of monoamine oxidase (MAO), particularly MAO-A and MAO-B, enzymes responsible for the breakdown of monoamine neurotransmitters including dopamine. Research has shown that substitution of an electron-withdrawing group at the N-9 position reduces inhibitory activity, suggesting that the methyl group increases electron density and enhances binding to the enzyme . This MAO inhibitory activity is the foundation for its neuropharmacological effects and potential therapeutic applications .

Beyond its MAO inhibition properties, 9-methyl-β-carboline has demonstrated a range of neuroprotective and neurorestorative effects in preclinical research. In vitro studies with dopaminergic neuron cell cultures have shown increased expression of tyrosine hydroxylase, enhanced neurite outgrowth, and regeneration of neurons after chronic toxin administration. The compound also appears to stimulate neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) . Rodent studies have further demonstrated elevated hippocampal dopamine levels, improved spatial learning performance, and restoration of tyrosine hydroxylase-expressing neurons in animal models of Parkinsonism .

The safety profile of 9-methyl-β-carboline indicates that it should be handled as a research chemical with appropriate precautions. While not classified as a hazardous substance under GHS by some suppliers, other sources note potential skin and eye irritation (H315, H319) requiring standard laboratory protective measures including gloves, safety goggles, and appropriate ventilation . The compound is stable under recommended storage conditions (powder at -20°C for up to 3 years, solutions at -80°C for 6 months) but may emit toxic fumes during combustion and should be kept away from strong acids, alkalis, and oxidizing agents . Notably, the compound may possess photosensitizing effects, and users should be aware of potential DNA damage mechanisms under photoexcited conditions, necessitating protection from light during handling .

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