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High Quality Sitagliptin phosphate monohydrate CAS 654671-77-9 with good price and fast delivery

Name: High Quality Sitagliptin phosphate monohydrate CAS 654671-77-9 with good price and fast delivery
Brand: HyperChem
SKU: pr2505081240
Price: 200 USD
Availability: InStock

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CAS No.:

654671-77-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Price valid (until):

2025-06-08

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Sitagliptin phosphate monohydrate
CAS number	654671-77-9
EINECS number	682-492-2
Synonym	MK0431; MK 0431; MK-0431; sitagliptin phosphate; sitagliptin phosphate monohydrate; (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one Phosphate Monohydrate; Sitagliptin phosphate hydrate
Description	Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses.
Structure
Molecular Formula	C16H18F6N5O5P
Molecular Weight	505.31 g/mol
Appearance	Solid powder
Quality Standard	USP Standard
Assay	≥98%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Store in cool place. Keep container tightly closed in a dry and well ventilated place.
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Sitagliptin phosphate monohydrate More Info

Sitagliptin phosphate monohydrate is the phosphate salt monohydrate form of sitagliptin, an oral antidiabetic agent primarily used for managing type 2 diabetes mellitus.

Mechanism of Action

Sitagliptin phosphate monohydrate is a potent, selective, competitive inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), with an IC50 of approximately 18–19 nM. DPP-4 normally degrades incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are released after meals.
By inhibiting DPP-4, sitagliptin increases the levels and prolongs the activity of GLP-1 and GIP, resulting in:
Increased glucose-dependent insulin secretion from pancreatic beta cells
Decreased glucagon secretion from pancreatic alpha cells
Improved glycemic control without causing hypoglycemia due to glucose-dependent action

Clinical Applications

Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Can be used as monotherapy or in combination with other antidiabetic agents such as metformin or sulfonylureas.
Does not cause weight gain and has a low risk of hypoglycemia compared to some other antidiabetic drugs.

Safety and Side Effects

Common side effects include:
Upper respiratory tract infections
Headache
Nasopharyngitis (stuffy or runny nose, sore throat)
Gastrointestinal symptoms such as stomach upset, diarrhea, or abdominal pain
Serious but rare side effects may include pancreatitis and hypersensitivity reactions.

Pharmacokinetics

Absorption: Approximately 87% orally bioavailable; peak plasma concentration reached within 1–2 hours after dosing.
Distribution: Volume of distribution about 198 L; plasma protein binding ~38%.
Metabolism: Minimal metabolism; primarily excreted unchanged in urine (~79%) via active tubular secretion involving human organic anion transporter-3 (hOAT-3).
Elimination half-life: Approximately 12.4 hours, allowing once-daily dosing.
Excretion: Mainly renal; dose adjustment recommended in renal impairment.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Sitagliptin phosphate monohydrate

Other Name:

1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-,(3R)-,phosphate,hydrate (1:1:1);1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-,phosphate (1:1),monohydrate;(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogen phosphate monohydrate;Sitagliptin phosphate monohydrate;1253056-03-9

CAS No.:

654671-77-9

Molecular Formula:

C16H15F6N5O.H3O4P.H2O

InChIKeys:

InChIKey=GQPYTJVDPQTBQC-KLQYNRQASA-N

Molecular Weight:

523.3240802

Exact Mass:

523.105530

EC Number:

1806241-263-5

UNII:

TS63EW8X6F

NCI Thesaurus Code:

C73811

ATC Code:

A10BH01|A10BD24

HScode:

2933990090

Categories:

Blood Glucose Regulators

Characteristics

PSA:

156

XLogP3:

1.66180

Appearance:

White or almost white crystalline powder

Boiling Point:

529.9ºC at 760 mmHg

Flash Point:

274.3℃

See More Sitagliptin phosphate monohydrate Properties 

Hazard Identification

Classification of the substance or mixture

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Sitagliptin phosphate monohydrate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bangladesh	Sitagliptin phosphate 99%	50 KG	Nov 13, 2023
Egypt	Sitagliptin phosphate monohydrate	3.00 KG	Oct 11, 2023

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