Dihydrohonokiol

1. Basic Chemical Information

• English Name : Dihydrohonokiol (DHH-B)
• Chinese Name : Dihydrohonokiol
• Chemical Name : 3'-Allyl-5-propyl-[1,1'-biphenyl]-2,4'-diol
• CAS No. : 219565-74-9
• Molecular Formula : C₁₈H₂₀O₂
• Molecular Weight : 268.35 g/mol
• SMILES : CCCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
• InChIKey : IBKNHHZQPPUDQJ-UHFFFAOYSA-N

Chemical Structure

2. Physicochemical Properties

• Appearance : White to off-white crystalline powder
• Solubility : Easily soluble in organic solvents such as methanol, ethanol, acetone, and DMSO; slightly soluble in water
• Stability : Stable at room temperature; store in a sealed, dry and light-proof container
• Melting Point : Approximately 82-84°C

3. Source and Preparation

Dihydrohonokiol is a hydrogenated derivative of the natural product Honokiol (CAS 35354-74-6), which can be obtained mainly through the following methods:

• Extraction and isolation from the bark of Magnolia officinalis (Magnoliaceae family)
• Chemical synthesis: Prepared by selective catalytic hydrogenation using Honokiol as the raw material

4. Biological Activities and Main Uses

• Neuroprotection : Inhibits neuronal damage, increases acetylcholine levels in the brain, and improves memory and cognition
• Antioxidant : Effectively scavenges free radicals and reduces oxidative stress and inflammatory responses
• Anti-inflammatory and Analgesic : Inhibits the NF-κB pathway and reduces the release of inflammatory factors
• Antitumor : Induces apoptosis of various tumor cells and inhibits their proliferation and metastasis
• Application Fields : Pharmaceutical intermediate, health product raw material, cosmetic additive, research reagent

5. Quality Standards (Research Grade)

• HPLC Purity : ≥98.0%; ≥99.0% (Reference Standard)
• Moisture : ≤1.0%
• Heavy Metals : ≤10 ppm
• Ignition Residue : ≤0.5%

6. Storage and Safety

• Storage Conditions : Sealed, light-proof, dry; stored at room temperature or refrigerated (2-8°C)
• Safety : Non-hazardous substance, low toxicity; avoid inhalation and long-term skin contact
• Usage Restriction : For research, pharmaceutical, health product and cosmetic raw material use only

7. Comparison with Honokiol