NMN 12 true-NAD+Booster ultra stable nucleotide for skin revitalization, DNA repair&sirtuin activation

Nicotinamide mononucleotide is also known as β-nicotinamide mononucleotide (NMN), which is a substrate for the synthesis of coenzyme I. At the same time, NMN is also used in anti-aging research. Studies have shown that β-NMN can also regulate insulin secretion and has an impact on mRNA expression levels. β-NMN has broad application prospects in the medical treatment field. β-Nicotinamide mononucleotide is the product of the reaction of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) and a key NAD+ intermediate. It improves glucose tolerance by restoring the NAD+ level in mice with type 2 diabetes induced by high-fat diet. It also enhances liver insulin sensitivity and partially restores the expression of genes related to oxidative stress, inflammatory response, and circadian rhythm through SIRT1 activation.

β- Nicotinamide mononucleotide is a precursor substance of the longevity protein's cofactor NAD+. NAD+ is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugar, fat, and amino acids, and participating in energy synthesis; NAD+ is also the sole substrate of the consuming enzymes of coenzyme I (the sole substrate of DNA repair enzyme PARP, the sole substrate of longevity protein Sirtuins, and the sole substrate of cyclic ADP-ribose synthase CD38/157). NAD+ is involved in all aspects of human metabolism and is a crucial coenzyme. Without NAD+, metabolism cannot function properly. When the elderly lack NAD+, various large and small problems arise. By supplementing extra NAD+, one can comprehensively anti-aging. Preclinical studies have shown that NMN has various pharmacological activities in cardiac and cerebral ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. NMN, as a precursor drug of NAD+, mainly functions in the body to synthesize NAD+ and exert pharmacological effects. All of these are related to the deficiency of NAD+.

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• β-Nicotinamide mononucleotide (β-NMN) is a naturally occurring and bioactive nucleotide that serves as the main source of cellular energy. It has antioxidant, anti-oxidative stress reduction, and anti-inflammatory effects. It offers the following benefits for the human body:

• (1) Studies have shown that by supplementing exogenous β-NMN to increase the content of NAD+ and NADH in the heart, it mimics the protective effect of IPC and enhances deacetylase activity, reducing infarct area, and achieving heart protection. When abnormal blood circulation occurs in the brain, it can trigger an acute cerebrovascular disease, and β-NMN has an improving effect on such situations.

• (2) Improving oxidative-related degenerative diseases and physical functional disorders Research shows that β-NMN can more directly and effectively increase NAD+ levels, promote the activation of the longevity factor Sirtuin Sirt1, achieve the effect of reducing cell damage and maintaining collagen, avoid skin dryness, wrinkling, collapse, relaxation and fine lines, thereby delaying skin aging. Cardiovascular diseases mainly occur due to irregular relaxation and contraction of myocardial cells, so treating cardiovascular diseases requires repairing and enhancing the energy of mitochondria in myocardial cells.

• (3) Therapeutic effects on metabolic diseases β-NMN can promote the biosynthesis of NAD+, and Nampt-mediated NAD+ biosynthesis is crucial for cell function, regulating insulin secretion of pancreatic islet cells and reducing blood sugar.